Volume 4 Supplement 1

Abstracts from the 3rd International Conference on Prevention and Infection Control (ICPIC 2015)

Open Access

Effectiveness of a hospital-wide educational programme for infection control to reduce the rate of healthcare associated infections and related sepsis (ALERTS)

  • S Hagel1, 2,
  • K Ludewig2,
  • A Moeser1,
  • C Pausch3,
  • A Scherag2, 4,
  • P Gastmeier5,
  • S Harbarth6 and
  • FM Brunkhorst2, 7, 8
Antimicrobial Resistance and Infection Control20154(Suppl 1):O17

DOI: 10.1186/2047-2994-4-S1-O17

Published: 16 June 2015

Introduction

The overarching objective of this clinical trial is to demonstrate the feasibility of an institutional programme to reduce the burden of Healthcare Associated Infections (HAIs) and related sepsis of at least 20%, without targeting only specific pathogens or hospital wards.

Methods

Prospective, quasi-experimental study covering all acute care units (27 general wards, 4 ICUs, overall 819 beds) at the Jena University Hospital. Surveillance for HAIs is performed by computerized antibiotic monitoring in patients with risk factors for HAIs (i.e. catheters, operations) on a daily basis. Following the 1st surveillance period (09/2011 to 08/2012) a multifaceted, pragmatic infection control programme, aimed at proper hand hygiene and bundles for the prevention of the four most common HAIs has been implemented. Subsequently, a 2nd surveillance phase (04/2013 to 08/2014) was conducted to measure the effect of the infection control programme.

Results

During the the first surveillance period 30.631 patients were admitted to the participating departments. According to CDC definitions we identified 1,637 HAIs, resulting in an overall incidence of 5.3 %. Based on clinical evaluation, irrespective of the CDC definitions, an additional 944 HAIs were detected (overall HAI rate, 8.4 % [n =2581]). A substantial proportion of patients had HAI associated severe sepsis or septic shock (lower respiratory tract infection, n = 279 [37 %]; surgical site infection, n = 114 [25 %]; primary sepsis, n = 110 [32 %]; urinary tract infection, n = 46 [8 %]; other, n = 87 [22 %]). The analysis of the second surveillance period is pending, the results however will be presented at the congress.

Conclusion

Our numbers reveal that a high number of HAIs are missed using CDC-definitions and therefore the magnitude of the problem might be underestimated. Furthermore, a high percentage of HAIs progress from localized infection to severe sepsis or septic shock, requiring ICU treatment.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
Center for Infectious Diseases and Infection Control, Jena University Hospital (JUH)
(2)
Center for Sepsis Control and Care, Jena University Hospital (JUH)
(3)
Statistics and Epidemiology, Institute for Medical Informatics
(4)
Research Group Clinical Epidemiology, Center for Sepsis Control and Care, Jena University Hospital (JUH)
(5)
Institute of Hygiene and Environmental Medicine, University Medicine
(6)
Infection Control Programme, Geneva University Hospitals
(7)
Paul Martini Sepsis Research Group
(8)
Center of Clinical Studies, Jena University Hospital (JUH)

Copyright

© Hagel et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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