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Table 1 Summary of included articles

From: Prolongation of length of stay and Clostridium difficile infection: a review of the methods used to examine length of stay due to healthcare associated infections

Author

Study type

Country

Statistical analysis

Results

Ananthakrishnan, McGinley, & Binion 2008

Retrospective case control

US

Multivariate regression

Three times the length of stay (CDI+IBD) vs. controls (IBD) IBD=irritable bowel disease

Bajaj et al. 2010

Retrospective case control

US

Multivariate regression

12.7-day case vs. 6.7-day control

Dubberke, Butler et al. 2008

Retrospective cohort

US

Multivariate regression, matched-pairs analysis

9.6-day cases vs. 5.8-day controls

Dubberke & Wertheimer 2009

Review

Not applicable

Not applicable

Not applicable

Ghantoji et al. 2010

Review

Not applicable

Not applicable

Not applicable

Kenneally et al. 2007

Retrospective cohort

US

Multiple logistic regression

27.3 (CDI) vs. 22.8 (non CDI)

Lawrence et al. 2007

Retrospective cohort

US

Multiple logistic regression

CDI stay twice as much non-CDI in ICU

Lumpkins et al. 2008

Prospective cohort

US

Multiple logistic regression

34.9day LOS with CDI vs. 19 LOS without CDI

Miller et al. 2002

Retrospective cohort

Canada

Not discussed

9% of 269 patients with CDI deemed to have extension of LOS due to CDI

Nguyen, Kaplan, Harris, & Brant 2008

Retrospective cohort

US

Multiple linear regression

65% increase in LOS in patients with CDI & Crohns disease 46% increase in LOS in patients with CDI & ulcerative colitis

OBrien, Lahue, Caro, & Davidson 2007

Retrospective cohort

US

Descriptive

6.4-day LOS in patients with primary CDI diagnosis

Pepin, Valiquette, & Cossette 2005

Retrospective case control

Canada

Not discussed

10.7-day additional LOS in patient with CDI

Song et al. 2008

Retrospective match cohort

US

Logistic regression Wilcoxon Linear regression

1-day LOS increase (with CDI)

4-day LOS increase (CDI) when compared to matched diagnosis related group DRG

    

Vonberg et al. 2008

Prospective match cohort

Germany

Wilcoxon Kolmogorov-Smirnov test

27-day LOS cases vs. 20-day LOS controls

Zerey et al. 2007

Retrospective cohort

US

Multiple logistic regression

16-day-longer LOS (with CDI)

Zilberberg et al. 2009

Retrospective cohort

US

Propensity score Multivariate analysis

6.1-day longer LOS (with CDI)