Antimicrobial stewardship program implementation timeline. The timeline depicts antimicrobial stewardship program milestones and interventions. A pneumonia order set and vancomycin dose-optimization protocol were implemented prior to the baseline period. Severe sepsis order sets and a parenteral to oral conversion protocol were implemented during the intervention period. The severe sepsis order sets included choices for initial antibiotic regimen by suspected source of infection and a schedule for continued therapy without automatic stop orders or requirements for physician justification. Individual agents included in the order sets were ampicillin, ampicillin-sulbactam, azithromycin, aztreonam, ceftriaxone, levofloxacin, linezolid, meropenem, piperacillin-tazobactam, rifampin and vancomycin. Antimicrobial agents in the parenteral to oral conversion protocol were fluconazole, levofloxacin, linezolid, metronidazole and voriconazole at the same dose and frequency.