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Table 3 Risk factors associated with CVC-associated BSI on NEO-KISS NICUs

From: The impact of staffing on central venous catheter-associated bloodstream infections in preterm neonates – results of nation-wide cohort study in Germany

Parameter Category OR CI 95% p-value
Realized staffing percentage Missing 1.25 (0.83-1.88) 0.289
<95% 1.47 (1.11-1.95) 0.008
≥95% 1=reference   
Birth weight <500 g 4.23 (2.46-7.3) <0.001
500-749 g 3.17 (1.85-5.45) <0.001
750-999 g 2.28 (1.47-3.53) <0.001
1000-1249 g 1.36 (0.86-2.14) 0.187
1250-1499 g 1=reference   
Gestational age (completed weeks) <27 weeks 3.97 (2.23-7.09) <0.001
27-28 weeks 3.04 (1.79-5.16) <0.001
29-30 weeks 1.99 (1.05-3.77) 0.035
>30 weeks 1=reference   
Length of stay 21-34 days 0.44 (0.29-0.69) 0.001
35-48 days 0.32 (0.21-0.49) <0.001
>48 days 0.29 (0.2-0.42) <0.001
<21 days 1=reference   
Standards for indication of hand hygiene Yes 0.61 (0.44-0.84) 0.002
No 1=reference   
Daily disinfection of the buttons of the ventilation systems Yes 0.68 (0.5-0.93) 0.014
No 1=reference   
Disinfection of the application port before medication infusion/connection of an infusion system Often 0.48 (0.31-0.77) 0.002
Rarely/no 1=reference   
Infusion preparation On ward without laminar-flow bench 1.53 (1.02-2.28) 0.039
In the pharmacy OR on ward with laminar-flow bench 1=reference   
  1. IQR, inter-quartile range. CI 95%, 95% confidence interval. CVC, central venous catheter. BSI, bloodstream infection. Realized staffing percentage, ratio of realized staffing / planned staffing * 100.
  2. Results of the multivariable regression analysis by GEE models.