P088: Monitoring multiresistant bacteria (MRB) to Principal Hospital Dakar: assessment of 1 year

Introduction

Bacterial resistance to antibiotics is a public health problem. Mastering their distribution is thus a priority. Thus, at the Principal Hospital of Dakar (HPD), a system for collecting and analyzing data of resistance has been established within the Committee against nosocomial infections.

Objectives

We present here the results compiled over a year to help guide prevention activities.

Methods

Prospective study from January 1 to December 31, 2012 at the HPD. Every day, multiresistant bacteria isolated in the laboratory are subject to a collection of clinical and biological data using a questionnaire. Enterobacteriaceae producing extended-spectrum beta-lactamase (ESBL) and derepressed cephalosporinases of Pseudomonas aeruginosa, multiresistant Acinetobacter and Methicillin Resistant Staphylococcus aureus isolates were analyzed. The data are then analyzed by Epi info.

Results

323 BMR were collected during the study period. The average age was 32 years [4 days, 95 years] and the sex ratio was 1.70. ESBL-producing Enterobacteriaceae (80%) followed by Acinetobacter multiresistant respectively (11%), ticarcillin-resistant Pseudomonas aeruginosa (4%) and methicillin-resistant Staphylococcus aureus (4%) were the most common isolates. ESBLs were as follows: 55% Klebsiella, E. coli 32% 11% Enterobacter, and others 2%. Blood cultures were the most common samples (40%), followed respectively by urinary tract infections (37%) and abscesses (16%). The pediatrics department was most affected (45%), followed respectively by the Internal Medicine and Resuscitation (each 23%) and Surgery (9%). A catheter was present in 91% of patients with sepsis and 66% of ESBL infections ESBL-producing Enterobacteriaceae were considered nosocomial.

Conclusion

This study shows the important place occupied by multi-resistant bacteria Principal Hospital. ESBL-producing Enterobacteriaceae represent the most common resistant organisms, mainly in the form of nosocomial infections.

Disclosure of interest

None declared