Pediatric transplants (n =192) | Adult transplants (n =990) | |||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
Variable | HR | p | HR | p | HR | p | HR | p |
Age group (yr) | .5 | |||||||
1–5 | Ref. | – | – | – | ||||
6–10 | 0.8 | |||||||
11–15 | 1.5 | |||||||
16+ | 0.9 | |||||||
<60 | – | Ref. | .04 | – | ||||
60+ | 0.6 | |||||||
Year of transplant | .03 | .03 | .42 | |||||
2008 | Ref. | Ref. | Ref. | |||||
2009 | 0.9 | 0.9 | 1.5 | – | ||||
2010 | 1.6 | 1.6 | 1.6 | |||||
2011 | 1.7 | 1.7 | 1 | |||||
2012 | 4 | 4 | 1.5 | |||||
Stem cell source | .32 | .13 | ||||||
Bone marrow | Ref. | – | Ref. | – | ||||
PBSC | 1.9 | 0.6 | ||||||
Cord blood | 1.2 | 0.8 | ||||||
GVHD prophylaxis | .06 | .13 | ||||||
CSP or FK506, with MTX | Ref. | – | Ref. | – | ||||
MMF regimen | 0.9 | 0.7 | ||||||
Other/none | 3.1 | 1.1 | ||||||
Conditioning regimen | .57 | .005 | .005 | |||||
Nonmyeloablative | Ref. | – | Ref. | Ref. | ||||
Myeloablative | 1.5 | 1.8 | 1.8 | |||||
Overall GVHD a | .24 | .34 | ||||||
Grades 0–I | Ref. | – | Ref. | – | ||||
Grades II–IV | 1.1 | 1.3 | ||||||
Gut GVHD a | .6 | .83 | ||||||
Grades 0–I | Ref. | – | Ref. | – | ||||
Grades II–IV | 0.6 | 0.9 | ||||||
Inpatient acquisition b | 1.7 | .02 | – | 2.1 | .12 | – |