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Table 3 Univariate and multivariate Cox proportional hazards models for CDI post-allogeneic HCT, per transplanting hospital

From: Evaluating risk factors for Clostridium difficile infection in adult and pediatric hematopoietic cell transplant recipients

  Pediatric transplants (n =192) Adult transplants (n =990)
  Univariate Multivariate Univariate Multivariate
Variable HR p HR p HR p HR p
Age group (yr)   .5       
1–5 Ref.     
6–10 0.8        
11–15 1.5        
16+ 0.9        
<60     Ref. .04  
60+      0.6    
Year of transplant   .03   .03   .42   
2008 Ref.   Ref.   Ref.    
2009 0.9   0.9   1.5   
2010 1.6   1.6   1.6    
2011 1.7   1.7   1    
2012 4   4   1.5    
Stem cell source   .32     .13   
Bone marrow Ref.    Ref.   
PBSC 1.9     0.6    
Cord blood 1.2     0.8    
GVHD prophylaxis   .06     .13   
CSP or FK506, with MTX Ref.    Ref.   
MMF regimen 0.9     0.7    
Other/none 3.1     1.1    
Conditioning regimen   .57     .005   .005
Nonmyeloablative Ref.    Ref.   Ref.  
Myeloablative 1.5     1.8   1.8  
Overall GVHD a   .24     .34   
Grades 0–I Ref.    Ref.   
Grades II–IV 1.1     1.3    
Gut GVHD a   .6     .83   
Grades 0–I Ref.    Ref.   
Grades II–IV 0.6     0.9    
Inpatient acquisition b 1.7 .02   2.1 .12  
  1. Abbreviations: PBSC (peripheral blood stem cells), GVHD (graft-versus-host disease), CSP (cyclosporine), FK506 (tacrolimus), MTX (methotrexate), MMF (mycophenolate mofetil), a GVHD onset modeled as time-dependent
  2. bdefined as inpatient stay within 3 days prior to the day of observation