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Table 1 Isolation density, resistance rates and incidence density of resistant isolates during the period 2008 – 2013

From: Antibiotic trends of Klebsiella pneumoniae and Acinetobacter baumannii resistance indicators in an intensive care unit of Southern Italy, 2008–2013

  Year  
  2008 2009 2010 2011 2012 2013 p-value*
Isolation density        
( per 1000 patient-days)
Klebsiella pneumoniae 38.0 48.5 22.3 31.9 41.6 55.9 0.497 (0.005, from 2010 to 2013)
Acinetobacter baumannii 20.4 19.3 29.8 49.0 50.3 58.1 0.002
Resistance rates, %        
(number of tested isolates)
3GC-resistant K. pneumoniae 88.7 (53) 69.4 (62) 41.9 (43) 67.2 (64) 87.0 (69) 81.6 (98) 0.806 (0.045 from 2010 to 2012)
ESBL-producing K. pneumoniae among 3GC-resistant K. pneumoniae 100 100 100 44.2 98.3 93.8 0.674
(39) (42) (18) (43) (59) (80)  
Carbapenem-resistant K. pneumoniae 0 (53) 9.7 (62) 2.3 (43) 37.5 (64) 63.8 (69) 59.2 (98) 0.010
Carbapenem resistant A. baumannii 87.5 (14) 95.0 (19) 96.2 (51) 98.9 (92) 93.2 (68) 96.6 (85) 0.021
Incidence density of resistant isolates ( per 1,000 patient-days)        
3GC-resistant K. pneumoniae 25.9 25.1 8.9 19.3 32.8 35.5 0.367 (0.027 from 2010 to 13)
ESBL-producing K. pneumoniae among 3GC-resistant K. pneumoniae 21.5 24.6 8.9 8.5 31.7 33.2 0.436
Carbapenem-resistant K. pneumoniae 0 3.5 0.5 10.8 24.1 25.7 0.009
Carbapenem-resistant A. baumannii 7.7 11.1 25.3 41.3 37.2 37.7 0.014
  1. *Linear regression
  2. Significant values are indicated in bold font
  3. Abbreviation: 3GC third-generation cephalosporin, ESBL Extended-spectrum beta-lactamase
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