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Table 4 Molecular characteristics of HR-GNR positive isolates

From: Prevalence, risk factors and molecular epidemiology of highly resistant gram negative rods in hospitalized patients in the Dutch region Kennemerland

Patient Hospital Species MLST HR-GNR typea, b, c ESBL gene(s) Acquired AMGdresistance genes Acquired QUIeresistance genes AMGdresistancef QUIeresistancef
P1 1 E. coli ST685 ESBL CTX-M-1 - - S S
P2 1 K. pneumoniae ST48 ESBL CTX-M-15, SHV-11 strA, strB oqxA, oqxB, QnrB66 S S
P3 1 E. coli ST69 Q&A - strA, strB, aph(3’)-Ia, aadA5, aac(3)-IId - R R
P4 2 E. coli ST5929g ESBL CTX-M-1 - - S S
P5 2 E. coli ST69 ESBL CTX-M-1 aadA5 - S S
P6 2 E. coli ST2178 ESBL CTX-M-3 - - S S
   E. coli ND ESBL ND ND ND S S
   K. pneumoniae ST22 ESBL CTX-M-15 strA, strB, aph (3’)-Ic, aac(3)-Iia, aac(6’) Ib-cr oqxA, oqxB, aac(6’) Ib-cr, QnrB66 R S
P7 2 E. coli ST349 ESBL CTX-M-14b strA, strB - S S
P8 2 E. coli ST93 ESBL CTX-M-14b - - S R
P9 2 E. coli ST131 ESBL CTX-M-27 strA, strB, aadA5 - S R
P10 2 E. cloacae ST50 ESBL CTX-M-1 aadA2, aadB oqxA, oqxB, QnrA1 I R
P11 2 E. cloacae ST421g ESBL CTX-M-9 aadB oqxA, oqxB, QnrA1 S S
P12 2 E. cloacae ST50 ESBL CTX-M-9 aadA2, aadB oqxA, oqxB, QnrA1 I R
   E. coli ST88 Q&A - aph(3’)-Ic - R R
P13 2 E. coli ST69 Q&A - strA, strB, aac(3)-IId - R R
P14 2 E. coli ST131 Q&A - strA, aac(3)-Iid, aadA5 - R R
P15 2 E. coli ST648 Q&A - aac(6’) Ib-cr aac(6’) Ib-cr R R
P16 3 E. coli ST10 ESBL CTX-M-14 strA, strB, aac(3)-IId, aadA1, aadA4, aac(6’) Ib-cr aac(6’) Ib-cr R S
P17 3 K. pneumoniae ST45 ESBL CTX-M-15 strA, strB, aac(3)-IIa, aac(6’) Ib-cr oqxA, oqxB, aac(6’) Ib-cr, QnrB66 R I
P18 3 E. coli ST131 ESBL CTX-M-27 - - S R
P19 3 E. coli ST635 ESBL SHV-12 strA, strB, aac(3)-IIb, aacA4, aac(6’) Ib-cr, aac(6’)-IIc aac(6’) Ib-cr, QnrB4, QnrB66 R I
P20 3 E. coli ST57 Q&A - aph(4)-Ia, aac(3)-IVa, aadA2 - R R
   E. coli ND Q&A - ND ND R R
P21 3 E. coli ST131 Q&A - strA, strB, aac(3)-Iid, aadA5 - R R
P22 3 S. maltophilia ST152g CTX-R - aph(3’)-IIc, aacA4, aac(6’) Ib-cr aac(6’) Ib-cr ND ND
  1. a: ESBL: Extended Spectrum Beta Lactamase; b: Q&A: combined resistance towards Fluoroquinolones and Aminoglycosides; c: CTX-R: resistance towards Co-trimoxazole; d: QUI: Fluoroquinolones; e: AMG: Aminoglycosides; f: resistance based on VITEK2 results; S sensitive, I intermediate, R resistant, ND not determined, NA not available, g new sequence type