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Table 1 Baseline characteristics of patients infected by Enterobacteriaceae producer of ESBL (ESBL+) and Enterobacteriaceae non-producer of ESBL (ESBL-)

From: Infections caused by extended-spectrum beta-lactamases producing Enterobacteriaceae: clinical and economic impact in patients hospitalized in 2 teaching hospitals in Dakar, Senegal

Variable, n (%)

ESBL+ infections (n = 110)

ESBL- infections (n = 76)

P-value

Demographics

   

 Male gender

68(61.8)

35(46.05)

0.037

 Mean age, years (range)

26.3(20.9–31.7)

28.1(21.5–34.7)

0.665

 Newborns (0–28 days)

22(20.0)

4(5.3)

0.005

 Premature babies

12(10.9)

2(2.6)

0.046

 Children (1 month-17 years)

37(33.6)

34(44.7)

0.167

 Adults (up to 17 years)

51(46.4)

38(50.0)

0.656

Comorbidity

   

 Sickle cell disease

10(9.1)

7(9.2)

1

 Malnutrition

10(9.1)

7(9.2)

1

 AIDS

8(7.2)

2(2.6)

0.203

Diagnostic at admission

   

 Severe malaria

19(17.3)

7(9.2)

0.808

 Gastroenteritis

16(14.5)

9(11.8)

0.666

 Respiratory disease

25(22.7)

10(9.1)

0.127

 Neurologic disorder

20(18.2)

12(15.8)

0.698

 Meningitis

10(9.1)

5(4.5)

0.596

 Tuberculosis

3(2.7)

3(3.9)

0.689

 Cancer

10(9.1)

6(7.9)

1

 Tetanus

4(3.6)

6(7.9)

0.321

Invasive procedure

   

 Surgical intervention

18(16.4)

18(23.7)

0.258

 Parental nutrition

24(21.8)

6(7.9)

0.014

 Mechanical ventilation

38(34.5)

7(9.2)

<0.0001

 Central venous catheter

84(76.4)

35(46.0)

<0.0001

 Urinary catheter

37(33.6)

13(17.1)

0.018

Type of infection

   

 Bloodstream infection

49(44.5)

20(26.3)

0.013

 Urinary tract infection

36(32.7)

31(40.8)

0.279

 Surgical site infection

13(11.8)

11(14.4)

0.656

 Respiratory infection

5(4.5)

12(15.8)

0.016

 Meningitidis

7(6.4)

2(2.6)

0.313

Time to infection, in days (95%CI)

   

 All patients

8.2(6.4–9.9)

4.8(2.7–6.9)

0.007

 Adults

11.3(8.8–13.8)

7.7(4.8–10.6)

0.029

 Children

6.6(3.1–10.2)

2(1.2–5.2)

0.028

 Newborns

3.5(2.2–4.8)

1(0.3–2.3)

0.059

Mean time after infection, days (95 % CI)

   

 All patients

14.2(12.6–16.3)

9.3(7.4–11.1)

<0.0001

 Adults

15.1(11.9–18.3)

8.9(7.2–10.6)

0.001

 Children

15.5(12.3–18.7)

10(6.3–13.7)

0.013

 Newborns

11.1(8.7–13.5)

6.2(5.8–13.0)

0.050

 Inadequate antibiotherapy prescription

97(88.2)

14(18.4)

<0.0001