Skip to main content

Table 2 Risk factors for fatal outcomes: results of univariate and multivariable analyses

From: Infections caused by extended-spectrum beta-lactamases producing Enterobacteriaceae: clinical and economic impact in patients hospitalized in 2 teaching hospitals in Dakar, Senegal

Variable, n (%) Fatal outcomes Univariate analysis Multivariable analysis
Yes (n = 69) No (n = 117) OR 95 % CI P-value OR 95 % CI P-value
Demographics         
 Male gender 34(49.3) 49(41.9) 1.3 0.7–2.4 0.361    
 Mean age, years (range) 27.1(20.4–33.8) 26.9(21.6–32.3)    0.489    
 Newborns (0–28 days) 16(23.2) 10(8.5) 3.2 1.4–7.5 0.008 4.5 2.4–37.8 0.025
P remature babies 9(13.0) 5(4.3) 3.4 1.1–9.9 0.042    
 Children (1 month–17 years) 17(24.6) 54(46.1) 2.6 1.4–5.0 0.005    
 Adults (up to 17 years) 36(52.2) 53(45.3) 1.3 0.7–2.4 0.448    
Comorbidity         
 Sickle cell disease 6(8.7) 11(0.5) 0.5 0.3–2.5 1    
 Malnutrition 4(5.8) 13(11.1) 0.5 0.5–1.5 0.296    
 AIDS 3(4.3) 7(5.9) 0.7 0.2–2.6 0.747
Diagnostic at admission         
 Gastroenteritis 6(8.7) 19(16.2) 0.5 0.2–1.3 0.184    
 Respiratory disease 18(26.1) 17(14.5) 2.1 0.9–4.3 0.079    
 Meningitis 11(15.9) 4(3.4) 5.3 1.7–16.6 0.004 2.3 1.5–4.9 <0.0001
 Tuberculosis 2(2.8) 4(3.4) 0.8 0–4.1 1    
 Cancer 12(20.3) 4(3.4) 5.9 1.9–18.3 0.002 2.7 1.6–6.6 0.001
 Neurologic disorder 8(11.5) 24(20.5) 0.5 0.2–1.2 0.159    
Invasive procedure         
 Surgical intervention 15(21.7) 21(17.9) 1.3 0.6–2.6 0.567    
 Parenteral nutrition 15(21.7) 15(12.8) 1.9 0.9–4.1 0.148    
 Mechanical ventilation 28(40.5) 17(14.5) 3.9 1.9–7.9 0.0002 6.1 3.1–124.6 0.040
 Central venous catheter 53(76.8) 66(56.4) 2.6 1.3–4.9 0.007    
 Urinary catheter 14(20.3) 36(30.8) 0.6 0.3–1.1 0.128    
 ESBL Production 52(75.4) 58(49.6) 3.1 1.6–5.9 <0.0001 5.3 3.1–19.9 0.008
Type of infection         
 Bloodstream infection 31(44.9) 38(32.5) 1.7 0.9–3.1 0.116
 Urinary tract infection 18(26.1) 49(41.9) 0.5 0.2–0.9 0.039    
 Meningitidis 7(10.1) 2(1.7) 6.5 1.5–25.7 0.014    
 Surgical site infection 9(13.0) 15(12.8) 1.0 0.4–2.4 1    
 Respiratory infection 4(6.8) 8(7.7) 0.8 0.2–2.7 1    
 Inadequate antibiotherapy prescription 49(71.0) 62(52.9) 2.3 1.2–4.3 0.013    
 Mean time to infection, days, (95 % CI) 5.9(4.3–7.5) 7.3(5.4–9.3)    0.838