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Table 1 Parameters and initial occupancy for the co-colonization model

From: Identifying conditions for elimination and epidemic potential of methicillin-resistant Staphylococcus aureus in nursing homes

Description

Symbol

Value (95 % CI)

Estimated or Observed

Initial occupancy in each compartment

Number of residents susceptible to any MRSA

S

350

observed

Number of residents colonized with non-USA300

I 1

79

observed

Number of residents colonized with USA300

I 3

14

observed

Number of residents co-colonized with non-USA300 and USA300

I b

3

observed

Total number of residents

N

446

observed

Model Parameters

Probability of admission of MRSA-colonized residents

λ

0.215

estimated

Discharge rate of susceptibles (per 3 months)

γ S

0.101

estimated

Discharge rate of MRSA-colonized (per 3 months)

γ I

0.074

estimated

Proportion of residents colonized with non-USA300 at baseline

w 1

0.823

observed

Proportion of residents colonized with USA300 at baseline

w 3

0.146

observed

Proportion of residents co-colonized with both strains at baseline

w b

0.031

observed

Acquisition rate for non-USA300a

b 1n

  

 - generalb

 

0.029 (0.022, 0.038)

estimated

 - w/o ABc

 

0.020 (0.014, 0.030)

estimated

 - with ABd

 

0.042 (0.030, 0.061)

estimated

Acquisition rate for USA300a

b 3n

  

 - generalb

 

0.006 (0.004, 0.011)

estimated

 - w/o ABc

 

0.004 (0.002, 0.010)

estimated

 - with ABd

 

0.009 (0.005, 0.019)

estimated

Clearance rate for non-USA300a

g n1

  

 - generalb

 

0.116 (0.088, 0.152)

estimated

 - w/o ABc

 

0.125 (0.086, 0.179)

estimated

 - with ABd

 

0.107 (0.074, 0.163)

estimated

Clearance rate for USA300a

g n3

  

 - generalb

 

0.137 (0.082, 0.228)

estimated

 - w/o ABc

 

0.155 (0.079, 0.328)

estimated

 - with ABd

 

0.125 (0.064, 0.266)

estimated

  1. AB, antibiotic use in the past 3 months
  2. aRelative frequency per 3 months
  3. bThe rate irrespective of antibiotic use in the past 3 months
  4. cThe rate corresponding to No level of antibiotic use in the past 3 months
  5. dThe rate corresponding to Yes level of antibiotic use in the past 3 months