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Table 1 Clinical characteristics of 20 patients with linezolid- and vancomycin-resistant Enterococcus faecium (LVRE) and phenotypic and genotypic features of nine further characterized LVRE isolates

From: Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation

Patient no.

Sex (age [yr])

Underlying Disease

Allogeneic HSCT

Localisation of LVRE (except bloodstream)

Bloodstream infection with LVRE

Previous linezolid exoposure

Clinical outcome

Previous hospital

MICs (mg/L) of the nine further characterized LVRE isolate

PFGE type

Linezolid

Vancomycin

Teicoplanin

Daptomycin

1

M (66)

lymphoma

yes

rectal

no

yes

death

A

–

–

–

–

–

2

M (64)

arthritis-metothrexat

no

urine

no

yes

discharge

unknown

–

–

–

–

–

3

F (34)

acute myeloic leukemia

yes

rectal, inguinal

yes

yes

death

C

–

–

–

–

–

4

F (47)

acute myeloic leukemia

yes

rectal, urine

no

unknwon

discharge

D

–

–

–

–

–

5

M (70)

acute myeloic leukemia

yes

rectal

yes

yes

discharge

E

–

–

–

–

–

6

F (54)

acute myeloic leukemia

yes

rectal, oral cavity, BAL

no

unknown

death

D

–

–

–

–

–

7

F (48)

myelodysplastic syndrome

yes

rectal, inguinal, wound

yes

yes

death

C

16

512

64

2

II

8

F (67)

acute lymphatic leukemia

yes

anal, inguinal, oral cavity

yes

unknown

discharge in palliative care

D

–

–

–

–

–

9

F (70)

myelodysplastic syndrome

yes

rectal, armpit, urine

no

yes

discharge

D

>32

512

128

2

I

10

F (68)

aplastic anemia

yes

urine

no

unknown

death

D

–

–

–

–

–

11

F (20)

acute myeloic leukemia

yes

urine

no

unknown

discharge

D

–

–

–

–

–

12

M (58)

myelodysplastic syndrome

yes

rectal, inguinal

no

unknown

discharge

D

32

512

128

2

I

13

F (58)

acute myeloic leukemia

yes

rectal, urine

no

unknown

discharge

D

16

512

128

2

I

14

M (53)

acute myeloic leukemia

yes

rectal, hair

yes

no

discharge

D

16

512

128

4

I

15

F (10)

histiocytosis

yes

rectal, urine

no

unknown

discharge

F

–

–

–

–

–

16

F (22)

acute myeloic leukemia

yes

rectal

no

no

discharge

D

16

512

128

2

I

17

M (62)

acute myeloic leukemia

yes

rectal, oral cavity

no

unknown

discharge

D

16

512

128

2

I

18

M (57)

acute myeloic leukemia

yes

rectal, urine

no

unknown

death

D

–

–

–

–

–

19

F (70)

acute myeloic leukemia

yes

rectal, oral cavity, urine

no

yes

discharge

G

32

512

128

2

IV

20

M (54)

multiple myeloma

no

rectal

no

yes

Discharge in palliative care

H

16

1024

<1

2

III

  1. Abbreviations: MIC minimum inhibitory concentration, PFGE pulsed-field gel electrophoresis