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Table 1 Clinical characteristics of 20 patients with linezolid- and vancomycin-resistant Enterococcus faecium (LVRE) and phenotypic and genotypic features of nine further characterized LVRE isolates

From: Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation

Patient no. Sex (age [yr]) Underlying Disease Allogeneic HSCT Localisation of LVRE (except bloodstream) Bloodstream infection with LVRE Previous linezolid exoposure Clinical outcome Previous hospital MICs (mg/L) of the nine further characterized LVRE isolate PFGE type
Linezolid Vancomycin Teicoplanin Daptomycin
1 M (66) lymphoma yes rectal no yes death A
2 M (64) arthritis-metothrexat no urine no yes discharge unknown
3 F (34) acute myeloic leukemia yes rectal, inguinal yes yes death C
4 F (47) acute myeloic leukemia yes rectal, urine no unknwon discharge D
5 M (70) acute myeloic leukemia yes rectal yes yes discharge E
6 F (54) acute myeloic leukemia yes rectal, oral cavity, BAL no unknown death D
7 F (48) myelodysplastic syndrome yes rectal, inguinal, wound yes yes death C 16 512 64 2 II
8 F (67) acute lymphatic leukemia yes anal, inguinal, oral cavity yes unknown discharge in palliative care D
9 F (70) myelodysplastic syndrome yes rectal, armpit, urine no yes discharge D >32 512 128 2 I
10 F (68) aplastic anemia yes urine no unknown death D
11 F (20) acute myeloic leukemia yes urine no unknown discharge D
12 M (58) myelodysplastic syndrome yes rectal, inguinal no unknown discharge D 32 512 128 2 I
13 F (58) acute myeloic leukemia yes rectal, urine no unknown discharge D 16 512 128 2 I
14 M (53) acute myeloic leukemia yes rectal, hair yes no discharge D 16 512 128 4 I
15 F (10) histiocytosis yes rectal, urine no unknown discharge F
16 F (22) acute myeloic leukemia yes rectal no no discharge D 16 512 128 2 I
17 M (62) acute myeloic leukemia yes rectal, oral cavity no unknown discharge D 16 512 128 2 I
18 M (57) acute myeloic leukemia yes rectal, urine no unknown death D
19 F (70) acute myeloic leukemia yes rectal, oral cavity, urine no yes discharge G 32 512 128 2 IV
20 M (54) multiple myeloma no rectal no yes Discharge in palliative care H 16 1024 <1 2 III
  1. Abbreviations: MIC minimum inhibitory concentration, PFGE pulsed-field gel electrophoresis
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