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Table 2 Multivariable Cox-proportional hazard regression of risk factors for 7-day mortality and hospital mortality after BSI with ESBL-positive or -negative E. coli and K. pneumoniae

From: E. coli bacteremia in comparison to K. pneumoniae bacteremia: influence of pathogen species and ESBL production on 7-day mortality

Parameter Parameter/ category 7-days mortality (stepwise) In-hospital mortalitya
HR CI95 P-value HR CI95 P-value
Interaction effect between pathogen species and ESBL-production E. coli ESBL-negative 1 = Reference   0.947 1 = Reference   0.084
E. coli ESBL-positive 1.16 0.70–1.90 0.571 1.22 0.88–1.68 0.228
K. pneumoniae ESBL-negative 0.98 0.64–1.50 0.926 1.39 1.07–1.82 0.015
K. pneumoniae ESBL-positive 1.05 0.49–2.27 0.894 1.01 0.60–1.67 0.983
Comorbidities Heart disease 1.55 1.09–2.21 0.014 1.23 0.97–1.56 0.087
Liver disease 1.96 1.40–2.74 <0.001 1.85 1.48–2.30 <0.001
Renal disease 2.86 1.99–4.10 <0.001 2.32 1.82–2.95 <0.001
Cancer/ immunological disease 1.66 1.21–2.28 0.002 1.58 1.28–1.95 <0.001
  1. ESBL extended-spectrum beta-lactamase, HR hazard ratio, CI95 95 % confidence interval, N.s. not significant
  2. aAnalyzing the same parameters as in 7-days mortality
  3. P-values <0.05 were considered statistically significant