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Table 1 Comparison of clinical characteristics between CRKP-BSI and CSKP-BSI patients

From: Epidemiology of Klebsiella pneumoniae bloodstream infections in a teaching hospital: factors related to the carbapenem resistance and patient mortality

Variable

Total (n = 114) n(%)

CRKP (n = 33) n(%)

CSKP (n = 81) n(%)

Univariate analysis

Multivariate analysis

OR(95% CI)

p-value

OR(95% CI)

p-value

General variables

Male sex

74(64.9)

22(66.7)

52(64.2)

1.12(0.5-2.6)

0.802

  

 Age,years, mean ± SD

56.37 ± 16.36

51.70 ± 16.26

58.27 ± 16.11

NA

0.051

  

 Poly-microbial BSI

11(9.6)

6(18.2)

5(6.2)

3.38 (1.0–12.0)

0.076

  

 Nosocomial infection

98(86.0)

33(100)

65(80.2)

NA

0.005

-

-

 ICU acquired infection

26(22.8)

14(42.4)

12(14.8)

4.24(1.7–10.7)

0.001

5.82(2.0–17.2)

0.002

Comorbidities

 Diabetes mellitus

30(26.3)

3(9.1)

27(33.3)

0.20(0.1–0.7)

0.008

  

 Chronic renal failure

8(7.0)

3(9.1)

5(6.2)

1.52(0.3–6.8)

0.689

  

 Chronic liver disease

20(17.5)

5(15.2)

15(18.5)

0.79(0.3–2.4)

0.668

  

 Liver cirrhosis

11(9.6)

2(6.1)

9(11.1)

0.52(0.1–2.5)

0.506

  

 Biliary tract disease

35(30.7)

9(27.3)

26(32.1)

0.79(0.3–1.9)

0.612

  

 Congestive heart failure

9(7.9)

4(12.1)

5(6.2)

2.10(0.5–8.4)

0.280

  

 Chronic obstructive pulmonary disease

3(2.6)

1(3.0)

2(2.5)

1.23(0.1–14.1)

1

  

 Malignancy

59(51.8)

12(36.4)

47(58.0)

0.41(0.2–1.0)

0.036

  

 Immunosuppression

26(22.8)

10(30.3)

16(19.8)

1.77(0.7–4.4)

0.223

  

 CCI,median (IQR)

3(2–6)

3(0–4)

4(2–6)

NA

0.005

-

-

Probable source of infection

 Lung

16(14.0)

5(15.2)

11(13.6)

1.14(0.4–3.6)

0.776

  

 Urinary

1(0.9)

0(0)

1(0.9)

NA

1

  

 Intra-abdominal

48(42.1)

12(36.4)

36(44.4)

0.71(0.3–1.6)

0.428

  

 Liver abscess

6(5.3)

1(3.0)

5(6.2)

0.48(0.1–4.2)

0.671

  

 Skin and soft tissue

12(10.5)

10(30.3)

2(2.5)

17.17(3.5–84.0)

<0.001

26.63(4.8–146.8)

<0.001

 Catheter

10(8.8)

5(15.2)

5(6.2)

2.71(0.7–10.1)

0.150

  

 Primary

27(23.7)

5(15.2)

22(27.2)

0.48(0.2–1.4)

0.171

  

Hospital events prior to onset of BSI

    

 Exposure to antimicrobial therapy a

74(64.9)

30(90.9)

44(54.3)

8.41(2.4–29.8)

<0.001

4.04(1.0–16.5)

0.052

 Surgery a

62(54.4)

21(63.6)

41(50.6)

1.71(0.7–3.9)

0.206

  

Events on the onset of BSI

       

 SOFA score,median (IQR)

3(1–6)

4(1–7)

3(1–5)

NA

0.098

  

 PBS,median (IQR)

1(1-2.25)

2(1–5)

1(0–2)

NA

<0.001

-

-

  1. ain the past 30 days prior to onset of BSI
  2. SD, standard deviation, IQR interquartile range, OR odds ratio, CI confidence interval, ICU intensive care unit, BSI bloodstream infection, CRKP carbapenem-resistant Klebsiella pneumoniae, CSKP carbapenem-sensitive Klebsiella pneumoniae, LOS length of stay, CCI Charlson comorbidity index, PBS Pitt bacteraemia score, SOFA score sequential organ failure assessment score, NA non-applicable