From: Daptomycin-induced eosinophilic pneumonia - a systematic review
Sex, n (%) | |
Male | 29 (83) |
Female | 6 (17) |
Age(years), mean ± SD | 65.4 ± 15 |
Daptomycin indication, n (%) | |
Osteomyelitis/diabetic foot infection | 11 (31) |
Prosthetic joint infection | 9 (26) |
Endocarditis | 5 (14) |
Bacteremia | 4 (11) |
Abscess | 3 (9) |
Other | 3 (9) |
Daptomycin dose (mg/kg/day), mean ± SD | 6.4 ± 1.6 |
Treatment duration at symptom onset (weeks), mean ± SD | 2.8 ± 1.6 |
Clinical findings, n (%) | |
Dyspnea | 33 (94) |
Fever | 20 (57) |
Cough | 13 (37) |
Requiring oxygen | 15 (43) |
Requiring mechanical ventilation | 12 (34) |
Infiltrates/opacities of CT/CXR, n (%) | 30 (86) |
BAL eosinophils %, mean ± SD | 32 ± 22.4 |
Peripheral eosinophilia, n (%) | 27 (77) |
Lung biopsy consistent with AEP, n (%) | 6 (17) |
Treatment, n (%) | |
Daptomycin discontinued only | 12 (34) |
Daptomycin discontinued plus corticosteroid | 23 (66) |