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Table 3 Compilation of available data on 35 cases of daptomycin-induced eosinophilic pneumonia

From: Daptomycin-induced eosinophilic pneumonia - a systematic review

Sex, n (%)
Male 29 (83)
Female 6 (17)
Age(years), mean ± SD 65.4 ± 15
Daptomycin indication, n (%)
Osteomyelitis/diabetic foot infection 11 (31)
Prosthetic joint infection 9 (26)
Endocarditis 5 (14)
Bacteremia 4 (11)
Abscess 3 (9)
Other 3 (9)
Daptomycin dose (mg/kg/day), mean ± SD 6.4 ± 1.6
Treatment duration at symptom onset (weeks), mean ± SD 2.8 ± 1.6
Clinical findings, n (%)
Dyspnea 33 (94)
Fever 20 (57)
Cough 13 (37)
Requiring oxygen 15 (43)
Requiring mechanical ventilation 12 (34)
Infiltrates/opacities of CT/CXR, n (%) 30 (86)
BAL eosinophils %, mean ± SD 32 ± 22.4
Peripheral eosinophilia, n (%) 27 (77)
Lung biopsy consistent with AEP, n (%) 6 (17)
Treatment, n (%)
Daptomycin discontinued only 12 (34)
Daptomycin discontinued plus corticosteroid 23 (66)
  1. AEP acute eosinophilic pneumonia, BAL bronchoalveolar lavage, CT computed tomography, CXR chest x-ray, SD standard deviation