Survivors | Non-survivors | p | |
---|---|---|---|
n = 134 | n = 127 | ||
Demographics | |||
Male sex | 73 (54.5) | 65 (51.2) | 0.59 |
Median age (range) | 64 (22–95) | 65 (24–101) | 0.81 |
Ward type | <0.001 a | ||
Medical ward | 66 (49.3) | 44 (34.6) | |
Surgical ward | 37 (27.6) | 14 (11.0) | |
ICU | 31 (23.1) | 69 (54.3) | |
Elective admission | 14 (10.4) | 13 (10.2) | 0.96 |
Comorbidities | |||
Malignancies | 58 (43.3) | 48 (51.6) | 0.37 |
Diabetes | 53 (39.6) | 50 (39.4) | 0.97 |
Chronic renal failure | 22 (16.4) | 45 (35.4) | <0.001 |
Hepatobiliary disorders | 25 (18.7) | 33 (26.0) | 0.16 |
Myocardial infarction | 19 (14.2) | 24 (18.9) | 0.30 |
Cerebrovascular disease | 11 (8.2) | 18 (14.2) | 0.13 |
Median (range) Charlson score | 4 (0–15) | 5 (0–14) | 0.09a |
Median (range) SAPS II score | 43 (14–82) | 58 (27–103) | <0.001 a |
Risk factors | |||
Central venous catheter | 89 (66.4) | 103 (81.1) | 0.007 a |
Drain | 37 (27.6) | 23 (18.1) | 0.07a |
Mechanical ventilation | 47 (35.1) | 64 (50.4) | 0.01 a |
Total parenteral nutrition | 28 (20.9) | 24 (18.9) | 0.69 |
Surgery | 81 (60.4) | 89 (70.1) | 0.10 |
Gastrointestinal surgery | 20 (14.9) | 21 (16.5) | 0.72 |
Renal replacement therapy | 23 (17.2) | 62 (48.8) | <0.001 a |
Antimicrobial therapy | 116 (86.6) | 120 (94.5) | 0.30 |
Antifungal therapy | 27 (20.1) | 24 (18.9) | 0.79 |
Immunosuppressive therapy | 33 (24.6) | 43 (33.9) | 0.10 |
Neutropenia | 10 (7.5) | 11 (8.7) | 0.72 |
Therapy | |||
Initial therapy | <0.001 b | ||
Echinocandin | 89 (66.4) | 76 (59.8) | |
Azole | 40 (29.9) | 12 (9.4) | |
Others (Amphotericin or combination) | 3 (2.2) | 5 (3.9) | |
None | 2 (1.5) | 34 (26.8) | |
Received initial therapy within 24 h | 58 (43.2) | 64 (50.4) | <0.001 b |
Infection Characteristics | |||
Species | 0.04 a | ||
C. albicans | 32 (23.9) | 27 (21.3) | |
C. glabrata | 39 (29.1) | 36 (28.3) | |
C. tropicalis | 29 (21.6) | 42 (33.1 | |
C. parapsilosis | 24 (17.9) | 9 (7.1) | |
Median (range) time to reporting positive culture, days | 2 (0–10) | 2 (0–10) | 0.08a |
Median (range) time to species identification, days | 5 (2–16) | 5 (2–22) | 0.001 a |
Median (range) Candida score | 2 (0–5) | 3 (0–5) | 0.01 |
Median (range) Pitts' bacteraemia score | 2 (0–11) | 5 (0–14) | <0.001 a |
Severe sepsis at time of culture | 64 (47.8) | 87 (68.5) | 0.001 a |
Concurrent bacterial infection | 59 (46.5) | 68 (53.5) | 0.12 |
Candida colonization/infection at other sites | 61 (45.5) | 57 (44.9) | 0.92 |