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Table 3 Characteristics of survivors vs. non-survivors

From: Candidemia in a major regional tertiary referral hospital – epidemiology, practice patterns and outcomes

 

Survivors

Non-survivors

p

n = 134

n = 127

Demographics

Male sex

73 (54.5)

65 (51.2)

0.59

Median age (range)

64 (22–95)

65 (24–101)

0.81

Ward type

  

<0.001 a

 Medical ward

66 (49.3)

44 (34.6)

 

 Surgical ward

37 (27.6)

14 (11.0)

 

 ICU

31 (23.1)

69 (54.3)

 

Elective admission

14 (10.4)

13 (10.2)

0.96

Comorbidities

Malignancies

58 (43.3)

48 (51.6)

0.37

Diabetes

53 (39.6)

50 (39.4)

0.97

Chronic renal failure

22 (16.4)

45 (35.4)

<0.001

Hepatobiliary disorders

25 (18.7)

33 (26.0)

0.16

Myocardial infarction

19 (14.2)

24 (18.9)

0.30

Cerebrovascular disease

11 (8.2)

18 (14.2)

0.13

Median (range) Charlson score

4 (0–15)

5 (0–14)

0.09a

Median (range) SAPS II score

43 (14–82)

58 (27–103)

<0.001 a

Risk factors

Central venous catheter

89 (66.4)

103 (81.1)

0.007 a

Drain

37 (27.6)

23 (18.1)

0.07a

Mechanical ventilation

47 (35.1)

64 (50.4)

0.01 a

Total parenteral nutrition

28 (20.9)

24 (18.9)

0.69

Surgery

81 (60.4)

89 (70.1)

0.10

 Gastrointestinal surgery

20 (14.9)

21 (16.5)

0.72

Renal replacement therapy

23 (17.2)

62 (48.8)

<0.001 a

Antimicrobial therapy

116 (86.6)

120 (94.5)

0.30

Antifungal therapy

27 (20.1)

24 (18.9)

0.79

Immunosuppressive therapy

33 (24.6)

43 (33.9)

0.10

Neutropenia

10 (7.5)

11 (8.7)

0.72

Therapy

Initial therapy

  

<0.001 b

 Echinocandin

89 (66.4)

76 (59.8)

 

 Azole

40 (29.9)

12 (9.4)

 

 Others (Amphotericin or combination)

3 (2.2)

5 (3.9)

 

 None

2 (1.5)

34 (26.8)

 

Received initial therapy within 24 h

58 (43.2)

64 (50.4)

<0.001 b

Infection Characteristics

Species

  

0.04 a

C. albicans

32 (23.9)

27 (21.3)

 

C. glabrata

39 (29.1)

36 (28.3)

 

C. tropicalis

29 (21.6)

42 (33.1

 

C. parapsilosis

24 (17.9)

9 (7.1)

 

Median (range) time to reporting positive culture, days

2 (0–10)

2 (0–10)

0.08a

Median (range) time to species identification, days

5 (2–16)

5 (2–22)

0.001 a

Median (range) Candida score

2 (0–5)

3 (0–5)

0.01

Median (range) Pitts' bacteraemia score

2 (0–11)

5 (0–14)

<0.001 a

Severe sepsis at time of culture

64 (47.8)

87 (68.5)

0.001 a

Concurrent bacterial infection

59 (46.5)

68 (53.5)

0.12

Candida colonization/infection at other sites

61 (45.5)

57 (44.9)

0.92

  1. All variables are denoted as number of patients with the characteristic or belong to the category n (%), unless otherwise stated
  2. Significant variables are reflected in bold and italics
  3. aFactors entered into multivariable logistic regression model
  4. bAdditional factors entered into multivariable logistic regression model including only treated episodes