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Table 3 Characteristics of survivors vs. non-survivors

From: Candidemia in a major regional tertiary referral hospital – epidemiology, practice patterns and outcomes

  Survivors Non-survivors p
n = 134 n = 127
Demographics
Male sex 73 (54.5) 65 (51.2) 0.59
Median age (range) 64 (22–95) 65 (24–101) 0.81
Ward type    <0.001 a
 Medical ward 66 (49.3) 44 (34.6)  
 Surgical ward 37 (27.6) 14 (11.0)  
 ICU 31 (23.1) 69 (54.3)  
Elective admission 14 (10.4) 13 (10.2) 0.96
Comorbidities
Malignancies 58 (43.3) 48 (51.6) 0.37
Diabetes 53 (39.6) 50 (39.4) 0.97
Chronic renal failure 22 (16.4) 45 (35.4) <0.001
Hepatobiliary disorders 25 (18.7) 33 (26.0) 0.16
Myocardial infarction 19 (14.2) 24 (18.9) 0.30
Cerebrovascular disease 11 (8.2) 18 (14.2) 0.13
Median (range) Charlson score 4 (0–15) 5 (0–14) 0.09a
Median (range) SAPS II score 43 (14–82) 58 (27–103) <0.001 a
Risk factors
Central venous catheter 89 (66.4) 103 (81.1) 0.007 a
Drain 37 (27.6) 23 (18.1) 0.07a
Mechanical ventilation 47 (35.1) 64 (50.4) 0.01 a
Total parenteral nutrition 28 (20.9) 24 (18.9) 0.69
Surgery 81 (60.4) 89 (70.1) 0.10
 Gastrointestinal surgery 20 (14.9) 21 (16.5) 0.72
Renal replacement therapy 23 (17.2) 62 (48.8) <0.001 a
Antimicrobial therapy 116 (86.6) 120 (94.5) 0.30
Antifungal therapy 27 (20.1) 24 (18.9) 0.79
Immunosuppressive therapy 33 (24.6) 43 (33.9) 0.10
Neutropenia 10 (7.5) 11 (8.7) 0.72
Therapy
Initial therapy    <0.001 b
 Echinocandin 89 (66.4) 76 (59.8)  
 Azole 40 (29.9) 12 (9.4)  
 Others (Amphotericin or combination) 3 (2.2) 5 (3.9)  
 None 2 (1.5) 34 (26.8)  
Received initial therapy within 24 h 58 (43.2) 64 (50.4) <0.001 b
Infection Characteristics
Species    0.04 a
C. albicans 32 (23.9) 27 (21.3)  
C. glabrata 39 (29.1) 36 (28.3)  
C. tropicalis 29 (21.6) 42 (33.1  
C. parapsilosis 24 (17.9) 9 (7.1)  
Median (range) time to reporting positive culture, days 2 (0–10) 2 (0–10) 0.08a
Median (range) time to species identification, days 5 (2–16) 5 (2–22) 0.001 a
Median (range) Candida score 2 (0–5) 3 (0–5) 0.01
Median (range) Pitts' bacteraemia score 2 (0–11) 5 (0–14) <0.001 a
Severe sepsis at time of culture 64 (47.8) 87 (68.5) 0.001 a
Concurrent bacterial infection 59 (46.5) 68 (53.5) 0.12
Candida colonization/infection at other sites 61 (45.5) 57 (44.9) 0.92
  1. All variables are denoted as number of patients with the characteristic or belong to the category n (%), unless otherwise stated
  2. Significant variables are reflected in bold and italics
  3. aFactors entered into multivariable logistic regression model
  4. bAdditional factors entered into multivariable logistic regression model including only treated episodes