Table 3 Mutations and fluoroquinolone susceptibility of Shigella flexneri strains
Point mutations | NAL-S & NOR-S strainsa (n = 93) | NAL-R strainsb (n = 303) | NAL-R & NOR-S strains (n = 84) | NOR-R strains (n = 148) |
|---|---|---|---|---|
No mutation | 46 (49.5) | 10 (3.3) | 5 (6.0) | 5 (3.4) |
GyrA-Ser83Leu | 14 (15.1) | 286 (94.4) | 77 (91.7) | 138 (93.2) |
GyrA-Asp87Asn/Gly | 11 (11.8) | 217 (71.6) | 28 (33.3) | 122 (82.4) |
GyrA-His211Tyr | 13 (13.9) | 280 (92.4) | 74 (88.1) | 135 (91.2) |
GyrB-Gln517Arg | 3 (3.2) | 10 (3.3) | 3 (3.6) | 3 (2.0) |
ParC-Ser80Ile | 15 (16.1) | 281 (92.7) | 75 (89.3) | 135 (91.2) |
ParC-Ser129Pro | 35 (37.6) | 116 (38.3) | 37 (44.0) | 48 (32.4) |
GyrA-Ser83Leu & ParC-Ser80Ile | 13 (13.9) | 280 (92.4) | 75 (89.3) | 134 (90.5) |
GyrA-Ser83Leu & ParC-Ser80Ile & GyrA-Asp87Asn/Gly | 11 (11.8) | 216 (71.3) | 28 (33.3) | 121 (81.8) |