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Table 3 Mutations and fluoroquinolone susceptibility of Shigella flexneri strains

From: Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China

Point mutations NAL-S & NOR-S strainsa (n = 93) NAL-R strainsb (n = 303) NAL-R & NOR-S strains (n = 84) NOR-R strains (n = 148)
No mutation 46 (49.5) 10 (3.3) 5 (6.0) 5 (3.4)
GyrA-Ser83Leu 14 (15.1) 286 (94.4) 77 (91.7) 138 (93.2)
GyrA-Asp87Asn/Gly 11 (11.8) 217 (71.6) 28 (33.3) 122 (82.4)
GyrA-His211Tyr 13 (13.9) 280 (92.4) 74 (88.1) 135 (91.2)
GyrB-Gln517Arg 3 (3.2) 10 (3.3) 3 (3.6) 3 (2.0)
ParC-Ser80Ile 15 (16.1) 281 (92.7) 75 (89.3) 135 (91.2)
ParC-Ser129Pro 35 (37.6) 116 (38.3) 37 (44.0) 48 (32.4)
GyrA-Ser83Leu & ParC-Ser80Ile 13 (13.9) 280 (92.4) 75 (89.3) 134 (90.5)
GyrA-Ser83Leu & ParC-Ser80Ile & GyrA-Asp87Asn/Gly 11 (11.8) 216 (71.3) 28 (33.3) 121 (81.8)
  1. NAL-S nalidixic acid susceptible, NAL-R nalidixic acid resistant, NOR-S norfloxacin susceptible, NOR-R norfloxacin resistant. aNAL-S & NOR-S strains, besides these strains, there were 3 strains showed NAL-S & NOR-I (intermediate resistant/susceptible) and 1 NAL-I & NOR-S strain. bNAL-R strains, among these strains, there were 71 NAL-R & NOR-I strains, which were not analysed in the table. The isolates that showed intermediate susceptible/resistant to NAL/NOR were not listed in detail in this table