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Table 5 Characteristics of the PMQR determinants positive Shigella flexneri isolates

From: Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China

Isolate number Serotype Year of isolation City Antibiotic susceptibility Target gene mutations PMQR determinants
NAL NOR gyrA gyrB parC
F12002 3b 2012 Nantong R R        qnrB
F12019 2b 2012 Yangzhou R I Ser83Leu Asp87Gly His211Tyr   Ser80Ile   aac(6′)-Ib-cr
F12037 2a 2012 Zhenjiang S I Ser83Leu   His211Tyr   Ser80Ile   aac(6′)-Ib-cr
F12066 4c 2012 Xuzhou R R Ser83Leu   His211Tyr   Ser80Ile   aac(6′)-Ib-cr
F12099 2b 2012 Yangzhou R I Ser83Leu Asp87Gly His211Tyr   Ser80Ile Ser129Pro aac(6′)-Ib-cr
F12149 4c 2012 Xuzhou R S Ser83Leu   His211Tyr   Ser80Ile Ser129Pro aac(6′)-Ib-cr
F12150 2a 2012 Xuzhou R I Ser83Leu   His211Tyr   Ser80Ile Ser129Pro aac(6′)-Ib-cr
F13055 4c 2013 Changzhou R R Ser83Leu   His211Tyr   Ser80Ile Ser129Pro qnrS
F13140 1a 2013 Yangzhou S S Ser83Leu   His211Tyr Gln517Arg Ser80Ile   aac(6′)-Ib-cr
F14054 2b 2014 Suqian R I Ser83Leu Asp87Asn His211Tyr   Ser80Ile   aac(6′)-Ib-cr, qnrS
F15099 2a 2015 Taizhou R R Ser83Leu Asp87Asn His211Tyr   Ser80Ile   qnrS
F15100 2a 2015 Taizhou R R Ser83Leu Asp87Asn His211Tyr   Ser80Ile   qnrS
F15101 2a 2015 Taizhou R R Ser83Leu Asp87Asn His211Tyr   Ser80Ile   qnrS
F15105 2a 2015 Taizhou R R Ser83Leu Asp87Asn His211Tyr   Ser80Ile   qnrS
F15106 2a 2015 Taizhou R R Ser83Leu Asp87Asn His211Tyr   Ser80Ile Ser129Pro qnrS
F15107 2a 2015 Taizhou R R Ser83Leu Asp87Asn His211Tyr   Ser80Ile   qnrS
  1. NAL nalidixic acid, NOR norfloxacin; antibiotic susceptibility, S susceptible, I intermediate resistant/susceptible, R resistant