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Table 1 Features of the eight mcr-1-harboring plasmids from seven E. coli isolated from humans and from food

From: Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

Host strain ID

Origin

Source

ST (CC)

MIC colistin [mg/L]

Resistance profile

mcr-1 harbouring plasmid

Plasmid size (bp)

Inc group

Mcr-1 gene cassette

Additional resistance genes on the mcr-1 harbouring plasmid

Reference

PC11

Chicken

Meat

ST1251

8

AM, CF

pPC11

59.830

IncI2

ISApl1-mcr-1-orf

none

[11]

PF11

Chicken

Meat

ST156 (CC156)

8

AM, CF, NA, CIP, TE

pPF11

33.308

IncX4

mcr-1-orf

none

[11]

PF52

Turkey

Meat

ST58 (CC155)

4

AM, CF, SMZ

pPF52

33.300

IncX4

mcr-1-orf

none

[11]

PF91

Turkey

Meat

ST1431

8

AM, CF, TE, C, SMZ

pPF91

33.310

IncX4

mcr-1-orf

none

[11]

CDF8

Human

UTI

nd

4

AM, CZ, CTX, FEP, NA, CIP, S, K

pCDF8

33.660

IncX4

mcr-1-orf

none

this study

ColR598

Human

Diarrhea

ST48 (CC10)

4

NA, CIP, TE

pColR598_1

33.299

IncX4

mcr-1-orf

none

this study

ColR598

Human

Diarrhea

ST48 (CC10)

4

NA, CIP, TE

pColR598_2

60.939

IncI2

mcr-1-orf

none

this study

ColR644SK1

Human

Diarrhea

ST117

4

AM, CF, TE, C, SMZ, TMP

pColR644SK1

60.952

IncI2

mcr-1-orf

none

this study

  1. Abbreviations: CC clonal complex; Inc. plasmid incompatibility group; ST sequence type; UTI urinary tract infection, not determined; MIC minimal inhibitory concentration; AM ampicillin; CF cephalothin; CZ cefazolin; CIP ciprofloxacin; NA nalidixic acid; K kanamycin; S streptomycin; SMZ sulfamethoxazole; TMP trimethoprim; TE tetracycline; C chloramphenicol