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Table 5 Univariate analysis of the 28-day mortality rate of K. pneumoniae BSI patients in the ICU

From: Clinical and molecular characteristics, risk factors and outcomes of Carbapenem-resistant Klebsiella pneumoniae bloodstream infections in the intensive care unit

Variable Died (n = 21) Survived (n = 27) Univariate analysis
P OR 95% CI
Sex (male, n)
Age (y) (mean ± SD) 57.74 ± 16.63 61.57 ± 13.69 0.448   
APACHE II score at admission 11.50 ± 5.53 10.07 ± 4.95 0.406   
APACHE II score on the day of bacteremia 18.29 ± 7.36 14.48 ± 6.11 0.031   
Liver failurea at admission 7 8 0.784 1.188 0.348—4.051
Kidney failureb at Admission 4 7 0.574 0.672 0.168—2.694
Liver failure on the day of bacteremia 11 7 0.06 3.143 0.933—10.584
Kidney failure on the day of bacteremia 6 6 0.614 1.400 0.377—5.195
Co-infection 14 20 0.575 0.700 0.2—2.445
CRKp 12(57.1%) 19(70.3%) 0.342 0.561 0.170—1.856
Diabetes mellitus 5(23.8%) 9(23.3%) 0.371 0.556 0.152—2.027
Hypertension 10(47.6%) 14(51.9%) 0.771 0.844 0.270—2.644
Coronary heart disease 2(9.5%) 2(7.4%) 0.792 1.316 0.170—10.208
Chronic renal failure 2(9.5%) 4(14.8%) 0.582 0.605 0.1—3.672
Solid organ tumor 4(19%) 7(25.9%) 0.574 0.672 0.168—2.694
Surgery in the past medical history 2(9.5%) 6(22.2%) 0.242 0.368 0.066—2.050
Prior healthcare-associated exposure 8(38.1%) 8(29.6%) 0.537 1.462 0.437—4.889
Glucocorticoid 8 12 0.658 0.769 0.240—2.460
Immunosuppressor 2(9.5%) 1(3.7%) 0.409 2.737 0.231—32.430
Central venous catheterization 17(81%) 23(85.2%) 0.696 0.739 0.161—3.383
Trachea cannula 9(42.9%) 5(18.5%) 0.066 3.3 0.899—12.108
Tracheotomy 6(27.3%) 11(40.7%) 0.325 0.545 0.162—1.833
Urinary catheter 13(61.9%) 17(16.9%) 0.940 0.956 0.295—3.102
Abdominal cavity drainage- tube 6(28.6%) 14(51.9%) 0.105 0.371 0.111—1.247
Stomach tube 18(85.7%) 23(85.2%) 0.959 1.043 0.305—0.593
Intrathoracic drain 0 4(14.8%) 0.121 0.523 0.394—0.693
External ventricular drainage tube care 1(4.7%) 0 0.438 0.426 0.305—0.593
  1. Abbreviations: OR odds ratio, CI confidence interval, CRKp carbapenem-resistant Klebsiella pneumoniae
  2. aLiver failure was defined as a serum bilirubin level of >3 mg/dl and/or prothrombin time (PT) of <50% on day 5 after surgery or thereafter; in patients with jaundice, it was defined as an increase in the serum bilirubin level or a PT < 50% on day 5 or thereafter [49]
  3. bKidney failure was defined as a creatinine level of ≥2 mg/dl or requirement for dialysis [33]