Age/Sex | RF | Symptoms | Imaging | Mucorale | Mycological diagnosis | EORTC/MSG criteria | Site of infection | Prophy/Treatment at Dx | Treatment | Outcome |
---|---|---|---|---|---|---|---|---|---|---|
39/F | AML | Fever, Cough CP | Nodule, surrounding GGO | Rhizopus microsporus or azygosporus | BAL Mucorales PCR+ | Poss w/PCR+ | Pulmonary | Vori, Caspo (8Â months) | LAMB, then posa | Death |
71/M | MM, auto HCT | Fever, Skin lesions | Nodule | Rhizopus microsporus or azygosporus | Skin swab culture +; BAL pan-fungal & Mucorales PCRs+ | Poss w/PCR+ | Disseminated: pulmonary, cutaneous | – | LAMB and posa | Death |
31/F | DLBCL | Fever Resp. failure Hypotension | Dense consolidations, pleural effusions | Rhizopus microsporus or azygosporus | BAL pan-fungal & Mucorales PCRs+; Autopsy histopath + | Proven | Pulmonary | Vori, Mica (1 month) | Nil – diagnosed after death | Death |
52/M | ALL | Fever, Resp. failure | Nodule | Rhizopus microsporus or azygosporus | BAL Mucorales PCR +; Autopsy histopath & culture + | Proven | Pulmonary | Flu | Nil – diagnosed after death | Death |
56/M | AML | Fever | Nodule, surrounding GGO | Rhizopus microsporus or azygosporus | BAL Mucorales PCR+ | Poss w/PCR+ | Pulmonary | Vori (5Â months) | LAMB, then posa | Hospice |
63/F | AML | Fever, Palatal lesions | Nodules w/cavitation; Diffuse sinus mucosal thickening | Rhizopus microsporus or azygosporus; Mucor circinelloides | Palate biopsy culture & histopath +; BAL culture, Mucorales & pan-fungal PCRs+ | Proven | Sinopulmonary | Flu | LAMB | Hospice |
73/M | AML | Chills, Resp. failure | Pulmonary nodules/consolidation; Masses w/in ventricles (Brain) | Rhizomucor pusillus | BAL Mucorales PCR+ | Poss w/PCR+ | Disseminated: pulmonary, CNS | Flu | LAMB | Death |
50/F | ALL, HCT | Forearm skin lesion | Normal | Rhizopus oryzae complex | Skin biopsy culture and Mucorales PCR + | Proven | Cutaneous | Flu | Surgery, LAMB + posa, then posa | Cure |
70/F | AML | Neutropenic fever, cough | Pulmonary nodules/consolidations | Rhizopus microsporus or azygosporus | BAL panfungal PCR+ | Poss w/PCR+ | Pulmonary | Posa prophylaxis ceased due to transaminitis | Â | Death |
71/M | MDS, HCT | Pulmonary nodules | Pulmonary nodules/consolidation | Cunninghamella bertholletiae | Autopsy histopath and Mucorales PCR+ | Proven | Pulmonary | Mica | Nil | Death |
45/F | AML | Neutropenic fever | Pulmonary nodules/consolidation | Rhizomucor pusillus | Lung tissue histopath+ | Proven | Pulmonary | Posa (subtherapeutic level) | Surgery + LAMB/terbinafine/isuvaconazole | Death |
59/F | MDS, HCT | Neutropenic fever, chest pain | Pulmonary nodules/kidney lesions | Rhizomucor meihei | Autopsy histopath, panfungal and Mucorales PCR+ | Proven | Disseminated – pulmonary, renal | Vori (transaminitis), Mica | Surgery | Death |