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Planning
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WHO Technical Unit
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• Form the WHO Steering Group (WSG)
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WSG
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• Draft the scope of the guideline; begin preparing the planning proposal
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• Identify potential members of the GDG and its Chair(s)
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• Obtain declaration of interests and manage any conflicts of interest among potential GDG members
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WSG and GDG
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• Formulate key questions in PICO format; prioritize outcomes
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WSG
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• Finalize the planning proposal and submit it to the GRC for review
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GRC
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• Review and approve the planning proposal
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Development
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Commissioning of systematic reviews
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• Develop a process to commission systematic reviews through a request for proposals
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• Perform systematic reviews of the evidence for each key question, and any additional literature reviews as needed
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• Evaluate the quality of the evidence for each important outcome, using GRADE methodology
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WSG
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• Convene meetings among the GDG members and review
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GDG
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• Formulate recommendations using the GRADE framework
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External review group
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• Conduct external peer review
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Publishing and updating
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WSG
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• Finalize the guideline document; perform copy-editing and technical editing; submit the final guideline to the GRC for review and approval
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GRC
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• Review and approve the final guideline
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WSG
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• Finalize the layout; proofread
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• Publish, disseminate, implement
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WHO Technical Unit
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• Evaluate and update
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