Intra-hospital differences in antibiotic use correlate with antimicrobial resistance rate in Escherichia coli and Klebsiella pneumoniae: a retrospective observational study

Table 4 Number of K. pneumoniae samples with antimicrobial susceptibility testing (AST) by origin across 18 departments in the years 2008–2016

Origin of the samples	Tested for	All nosocomial samples (N = 648)	Samples obtained after 2 to 5 hospital days (N = 124)	Samples obtained after 5 hospital days (N = 524)
Urine	AM-CL, Amox/AMP^b, Quinolones, TMP-SMX	329 (51%)	72 (58%)	257 (49%)
Urine	CFP, CFT, Gent, MER^a, PIP-TZ	51 (8%)	12 (10%)	39 (7%)
Blood	AM-CL, Amox/AMP^b, CFP, CFT, Gent, MER^a, PIP-TZ, Quinolones, TMP-SMX	89 (14%)	9 (7%)	80 (15%)
Respiratory samples	AM-CL, Amox/AMP^b, CFP, CFT, Gent, MER^a, PIP-TZ, Quinolones, TMP-SMX	69 (11%)	16 (13%)	53 (10%)
Wound swabs	AM-CL, Amox/AMP^b, CFP, CFT, Gent, MER^a, PIP-TZ, Quinolones, TMP-SMX	22 (3%)	3 (2%)	19 (4%)
Other	AM-CL, Amox/AMP^b, CFP, CFT, Gent, MER^a, PIP-TZ, Quinolones, TMP-SMX	139 (21%)	24 (19%)	115 (22%)
Other	PIP-TZ	138 (21%)	24 (19%)	114 (22%)

Abbreviations: Amox amoxicillin, AMP ampicillin, AM-CL amoxicillin-clavulanic acid, CFP cefepime, CFT ceftriaxone, Gent gentamicin, MER meropenem, PIP-TZ piperacillin-tazobactam, TMP-SMX trimethoprim-sulfamethoxazole
^aNot included in the models for resistance because only two samples were resistant to Meropenem
^bNot included in the models for resistance because all samples were resistant to Amoxicillin/Ampicillin

ISSN: 2047-2994