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Table 5 Antibiotic resistance and association with antibiotic use for K. pneumoniae

From: Intra-hospital differences in antibiotic use correlate with antimicrobial resistance rate in Escherichia coli and Klebsiella pneumoniae: a retrospective observational study

 

Resistance

Association with antibiotic use

No. of tests/strata

Proportion resistant (95% CI)

Odds ratio (95% CI)

p-value

Amoxicillin-clavulanic acid

648 / 115

17 (14–21)

1.07 (1.01–1.14)

0.025

Ceftriaxone

369 / 92

10 (5–18)

1.12 (0.52–2.45)

0.77

Cefepime

369 / 92

3 (1–9)

0.86 (0.59–1.25)

0.43

Piperacillin-tazobactam

369 / 92

21 (17–25)

0.84 (0.61–1.18)

0.32

Quinolones

648 / 115

6 (3–9)

1.37 (0.94–2.01)

0.10

Trimethoprim-sulfamethoxazole

648 / 115

15 (12–19)

2.02 (1.44–2.84)

< 0.001

Gentamicin

369 / 92

8 (4–16)

1.82 (0.13–25.42)

0.66

Combined

3420 / 713

12 (8–16)

1.06 (0.99–1.14)

0.07

  1. Results from logistic mixed effects models. The odds ratios represent the relative change in the odds for resistance for an increase in antibiotic use by 5 DDD/100 bed-days. Strata refers to year/department combinations
  2. CI confidence interval