Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection

Table 3 Univariate and Multivariate Cox Regression Analysis for the Risk for Subsequent Multidrug-resistant Gram-negative Bacteria (MDRGNB) Infection after Hospital Discharge

	Univariate analysis			Multivariate analysis
	HR	(95% CI)	p-value	HR	(95% CI)	p-value
Age (per year increase)	1.03	(1.02–1.05)	< 0.001	1.02	(1.01–1.03)	0.007
Male sex	0.97	(0.68–1.37)	0.84	–	–	–
LTCF residence	2.59	(1.43–4.70)	0.002	–	–	–
Long-term hemodialysis	1.30	(0.53–3.19)	0.56	–	–	–
Diabetes mellitus	1.13	(0.77–1.64)	0.53	–	–	–
Malignancy	1.41	(0.95–2.09)	0.09	1.66	(1.12–2.47)	0.012
End-stage renal disease	0.96	(0.39–2.34)	0.93	–	–	–
Liver cirrhosis	0.65	(0.32–1.33)	0.24	–	–	–
Congestive heart failure	2.79	(1.83–4.27)	< 0.001	1.70	(1.08–2.68)	0.021
COPD	2.73	(1.80–4.15)	< 0.001	1.60	(1.03–2.48)	0.038
Cerebrovascular accident	1.75	(1.17–2.64)	0.007	–	–	–
Presence of pressure sore	2.32	(1.31–4.12)	0.004	–	–	–
Central vascular catheter^a,b	1.83	(1.01–3.32)	0.046	–	–	–
Long-term urinary catheter^b	1.72	(1.00–3.00)	0.05	–	–	–
Antibiotics exposure^c	3.54	(2.03–6.17)	< 0.001	2.20	(1.25–3.90)	0.007
Intensive care unit admission^c	1.26	(0.59–2.70)	0.55	–	–	–
Receiving tracheal intubation^c	2.39	(1.25–4.56)	0.008	–	–	–
MDRGNB culture positive^c,d	7.19	(5.08–10.19)	< 0.001	5.35	(3.72–7.71)	< 0.001

Abbreviations: LTCF long-term care facility, COPD chronic obstructive pulmonary disease
^aIncludes Port-A catheter, Hickman catheter, permcath catheter, double-lumen catheter, and peripherally inserted central catheter
^bAt the time of index hospitalization discharge
^cDuring index hospitalization
^dIncluding positive MDR-GNB culture from either surveillance or clinical culture of any anatomical site

ISSN: 2047-2994