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Table 3 Baseline and Clinical characteristics of patients

From: Incidence and outcomes of multidrug-resistant gram-negative bacteria infections in intensive care unit from Nepal- a prospective cohort study

Variables

Uninfected patients; n = 41

Patients with MDR-GNB; n = 64

Patients with non-MDR-GNB; n = 10

p-value

Age (years)

43.5(28–56)

53(27–65)

55(40–60)

0.27

Age categories

  < 65

25(61%)

49(76%)

8(80%)

0.18

  > 65

16(39%)

15(23%)

2(20%)

 

Sex(M/F)

19/23

28/35

4/6

0.95

Reason for admission

 Cardiovascular

9(22%)

16(25%)

6 (60%)

0.89

 Respiratory

27(66%)

44 (69%)

3(30%)

 

 Digestive/Liver

1(2%)

2(3%)

0 (0%)

 

 Renal

1(2%)

2(3%)

1 (10%)

 

 Neurological

3(7%)

0 (0%)

0(0%)

 

Medical/Surgical admission

35/6

50/14

7/3

0.47

CCI Score

0(0–2)

1(0–3)

1(0–1)

0.77

APACHE Score

 At 24 h

13.5(11–16)

16(12–21)

13(12–15)

0.15

 At 48 h

13(11–15)

17(12–20)

13(12–14)

0.08

Duration of ventilation

0(0–7)

10(6–16)

7.5(6–11)

0.22

Previous antibiotic therapy

17(41%)

61(95%)

6(60%)

< 0.001

Aminoglycoside

5(12%)

18(28%)

2(20%)

0.13

Fluoroquinolone

3(7%)

20(31%)

2(20%)

0.009

Macrolide

3(7%)

13(20%)

2(20%)

0.15

Beta-lactam/Beta-lactamase inhibitor

4(10%)

27(42%)

4(40%)

0.001

Cephalosporin

5(12%)

10(16%)

0(0%)

0.49

Carbapenem

1(2%)

22((34%)

0(0%)

< 0.001

Tigecycline

0(0%)

4(6%)

0(0%)

0.29

Clindamycin

0(0%)

6(9%)

0(0%)

0.12

Vancomycin or teicoplanin

0(0%)

23(36%)

1(10%)

< 0.001

Metronidazole

0(0%)

7(11%)

0(0%)

0.06

Duration of prior antibiotics used (days)

0(0–6)

7(6–8)

4(0–5)

< 0.001

Health-care-associated infection

 

61(95%)

2(20%)

< 0.001

  1. Note: Values are in median (IQR), number, number (%)