Variables | Uninfected patients; n = 41 | Patients with MDR-GNB; n = 64 | Patients with non-MDR-GNB; n = 10 | p-value |
---|---|---|---|---|
Age (years) | 43.5(28–56) | 53(27–65) | 55(40–60) | 0.27 |
Age categories | ||||
< 65 | 25(61%) | 49(76%) | 8(80%) | 0.18 |
> 65 | 16(39%) | 15(23%) | 2(20%) | |
Sex(M/F) | 19/23 | 28/35 | 4/6 | 0.95 |
Reason for admission | ||||
Cardiovascular | 9(22%) | 16(25%) | 6 (60%) | 0.89 |
Respiratory | 27(66%) | 44 (69%) | 3(30%) | |
Digestive/Liver | 1(2%) | 2(3%) | 0 (0%) | |
Renal | 1(2%) | 2(3%) | 1 (10%) | |
Neurological | 3(7%) | 0 (0%) | 0(0%) | |
Medical/Surgical admission | 35/6 | 50/14 | 7/3 | 0.47 |
CCI Score | 0(0–2) | 1(0–3) | 1(0–1) | 0.77 |
APACHE Score | ||||
At 24 h | 13.5(11–16) | 16(12–21) | 13(12–15) | 0.15 |
At 48 h | 13(11–15) | 17(12–20) | 13(12–14) | 0.08 |
Duration of ventilation | 0(0–7) | 10(6–16) | 7.5(6–11) | 0.22 |
Previous antibiotic therapy | 17(41%) | 61(95%) | 6(60%) | < 0.001 |
Aminoglycoside | 5(12%) | 18(28%) | 2(20%) | 0.13 |
Fluoroquinolone | 3(7%) | 20(31%) | 2(20%) | 0.009 |
Macrolide | 3(7%) | 13(20%) | 2(20%) | 0.15 |
Beta-lactam/Beta-lactamase inhibitor | 4(10%) | 27(42%) | 4(40%) | 0.001 |
Cephalosporin | 5(12%) | 10(16%) | 0(0%) | 0.49 |
Carbapenem | 1(2%) | 22((34%) | 0(0%) | < 0.001 |
Tigecycline | 0(0%) | 4(6%) | 0(0%) | 0.29 |
Clindamycin | 0(0%) | 6(9%) | 0(0%) | 0.12 |
Vancomycin or teicoplanin | 0(0%) | 23(36%) | 1(10%) | < 0.001 |
Metronidazole | 0(0%) | 7(11%) | 0(0%) | 0.06 |
Duration of prior antibiotics used (days) | 0(0–6) | 7(6–8) | 4(0–5) | < 0.001 |
Health-care-associated infection | 61(95%) | 2(20%) | < 0.001 |