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Table 2 Demographic and clinical characteristics of the patients receiving carbapenem treatment

From: Evaluation of carbapenem use in a tertiary hospital: antimicrobial stewardship urgently needed

Characteristic

2010

2011–2013

2014–2016

2017

Patients N

209

440

787

338

Male sex N (%)

132 (63.2)

272 (61.8)

285 (36.2)

127 (37.6)

Age (years)

60 (46–72)

58 (45–70)

57 (46–69)

58 (42–67) *

Department of Medicine (%) a

119 (56.9)

242 (55.0)

430 (54.6)

203 (60.1)

duration of stay in the hospital

21 (13–30)

22 (14–33)

18 (11–27) *#

19 (12–28) #

eGFR b (ml·min−1)

91.9

(65.8–105.7)

99.5 *

(75.2–115.2)

101.8*

(80.0-118.2)

98.65*†

(64.8–113.2)

Carbapenem duration (days)

7 (5–11)

8 (5–12) *

8 (6–12) *

8 (5–12)

Total drug costs

($)

3713.9

(2121.0–6489.0)

5728.9 *

(3104.0–9054.3)

4931.2 *

(2781.1–8900.5)

5315.3 *

(2521.4–10,418.6)

Hospital costs

($)

6254.8

(3424.7–10,819.4)

10,130.9 *

(5391.9–16,961.9)

8929.2 *

(4796.9–17,886.1)

10,427.0 *†

(4752.2–20,489.7)

  1. *P < 0.05 when compared with 2010; #P < 0.05 when compared with 2011–2013; P < 0.05 when compared with 2014–2016
  2. aThe clinical departments were simply dichotomized into medicine and surgery
  3. beGFR, estimated glomerular filtration rate. It was calculated by the formula of Chronic Kidney Disease-EPI