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Table 2 Incidence (densities) of infections with third generation cephalosporin-resistant Enterobacteriaceae (3GCREB), ATHOS project, 2014–2015, Germany

From: Incidence of infections due to third generation cephalosporin-resistant Enterobacteriaceae - a prospective multicentre cohort study in six German university hospitals

Parameter

Category

3GCREB CAI incidence per 100,000 admissions (95% CI)

3GCREB CAI incidence per 100 admissions (95% CI)

3GCREB HAI incidence per 100 admissions (95% CI)

3GCREB HAI incidence density per 1000 patient days (95% CI)

3GCREB

total

276 (263–290)

0.28 (0.26–0.29)

0.31 (0.29–0.32)

0.52 (0.50–0.55)

Species

E. coli

157 (147–168)

0.16 (0.15–0.17)

0.12 (0.12–0.13)

0.21 (0.20–0.23)

Enterobacter spp.

38 (33–44)

0.04 (0.03–0.04)

0.08 (0.08–0.09)

0.14 (0.13–0.16)

Klebsiella spp.

45 (40–52)

0.05 (0.04–0.05)

0.05 (0.05–0.06)

0.09 (0.08–0.10)

Citrobacter spp.

13 (10–16)

0.01 (0.01–0.02)

0.02 (0.02–0.03)

0.04 (0.03–0.05)

Other species a

22 (18–26)

0.02 (0.02–0.03)

0.03 (0.02–0.03)

0.04 (0.04–0.05)

Resistance

all 3GCREB

    

 only 3GCR

100 (92–109)

0.10 (0.09–0.11)

0.16 (0.15–0.17)

0.27 (0.25–0.29)

 + FQR

169 (159–180)

0.17 (0.16–0.18)

0.14 (0.13–0.15)

0.24 (0.23–0.26)

 + CR

6 (5–9)

0.006 (0.005–0.009)

0.008 (0.006–0.011)

0.014 (0.011–0.019)

E. coli

    

 only 3GCR

36 (31–41)

0.04 (0.03–0.04)

0.04 (0.03–0.04)

0.06 (0.05–0.07)

 + FQR

121 (112–130)

0.12 (0.11–0.13)

0.09 (0.08–0.10)

0.15 (0.14–0.16)

 + CR

1 (0–2)

0.001 (0.000–0.002)

0.002 (0.001–0.003)

0.003 (0.001–0.005)

Enterobacter spp.

   

 only 3GCR

29 (25–34)

0.03 (0.03–0.03)

0.07 (0.06–0.07)

0.11 (0.10–0.13)

 + FQR

8 (6–10)

0.01 (0.01–0.01)

0.01 (0.01–0.02)

0.02 (0.02–0.03)

 + CR

1 (1–3)

0.001 (0.001–0.003)

0.003 (0.002–0.005)

0.006 (0.003–0.009)

Klebsiella spp.

    

 only 3GCR

10 (8–13)

0.01 (0.01–0.01)

0.02 (0.01–0.02)

0.03 (0.02–0.04)

 + FQR

31 (27–36)

0.03 (0.03–0.04)

0.03 (0.03–0.04)

0.05 (0.05–0.06)

 + CR

4 (3–6)

0.004 (0.003–0.006)

0.003 (0.002–0.005)

0.006 (0.003–0.009)

Infections

SSI

17 (14–21)

0.02 (0.01–0.02)

0.05 (0.05–0.06)

0.09 (0.08–0.10)

UTI

151 (141–161)

0.15 (0.14–0.16)

0.11 (0.11–0.12)

0.19 (0.18–0.21)

LRTI

27 (23–32)

0.03 (0.02–0.03)

0.07 (0.07–0.08)

0.12 (0.11–0.13)

BSI

38 (33–43)

0.04 (0.03–0.04)

0.04 (0.04–0.05)

0.07 (0.06–0.08)

Other infections b

43 (38–48)

0.04 (0.04–0.05)

0.03 (0.02–0.03)

0.05 (0.04–0.06)

  1. a “Other Enterobacteriaceae species” include Cedecea, Hafnia, Morganella, Pantoea, Proteus, Providencia, Raoultella, and Serratia species. b “Other infections” includes all other infection types. 3GCREB = third generation cephalosporin-resistant Enterobacteriaceae, 3GCR third generation cephalosporin resistance, FQR fluoroquinolone resistance, CR carbapenem resistance, 3GCR + CR carbapenem resistant Enterobacteriaceae (CRE), CAI community-acquired infection, HAI hospital-acquired infection, SSI surgical site infection, UTI urinary tract infection, LRTI lower respiratory tract infection, BSI bloodstream infection, 95% CI 95% confidence interval