Skip to main content

Table 4 Genotypic characterization of NDM-positive isolates co-transferring blaNDM-1 and PMQRs

From: Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and blaNDM gene in Enterobacteriaceae causing neonatal septicaemia

Strain no.

Organism

NDM

PMQR

Other Resistance genes

MEM MIC

CIP MIC

Plasmid size

Plasmid type

Plasmid addiction system

Integron

EN5132

Escherichia coli

bla NDM-1

aac(6′)-Ib-cr

bla CTX-M, TEM, OXA

armA

2

> 32

212, 6, 3

FIB,A/C,FIIK,FII,N

PemK, CcdAB, Hok-Sok

intI1

EN5132.T1

E. coli J53 Fox-azide

bla NDM-1

aac(6′)-Ib-cr

bla CTX-M, TEM, OXA

armA

2

0.047

212

A/C

–

intI1

EN5127

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr, qnrS

aac(6′)-Ib, bla SHV, rmtC

24

> 32

210, 4,3

A/C,FIIK,N

–

intI1

EN5127.T1

E. coli J53 Fox-azide

bla NDM-1

aac(6′)-Ib-cr

aac(6′)-Ib, rmtC

2

0.016

210

N, A/C

–

IntI1

EN5127.T2

E. coli J53 Cip-Azide

bla NDM-1

aac(6′)-Ib-cr

aac(6′)-Ib, rmtC

6

0.5

210

N, A/C

–

IntI1

EN5150

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib, bla CTX-M, SHV, OXA

4

> 32

248

FIIK,

PemK

IntI1

EN5150.T1

E. coli J53 Fox-azide

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib bla CTX-M, OXA

4

0.25

248

FIIK,

–

IntI1

EN5150.T2

E. coli J53 Cip-Azide

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib bla CTX-M, OXA

4

0.25

248

FIIK,

 

IntI1

EN5151

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib bla CTX-M, SHV,OXA

2

> 32

248, 128

FIIK,

–

IntI1

EN5151.T1

E. coli J53 Fox-azide

bla NDM-1

qnrB

aac(6′)-Ib,

1

0.064

248

FIIK,

–

IntI1

EN5151.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrB

aac(6′)-Ib

0.5

0.047

248

FIIK,

 

IntI1

EN5163

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

bla CTX-M, SHV, OXA, aac(6′)-Ib

6

> 32

266, 154

FIIK

–

IntI1

EN5163.T1

E. coli J53 Fox-azide

bla NDM-1

qnrB

aac(6′)-Ib

3

0.125

266

FIIK

–

IntI1

EN5163.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrB

aac(6′)-Ib

2

0.125

266

FIIK

 

IntI1

EN5165

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib bla CTX-M, SHV, OXA

12

> 32

266, 154

FIIK

–

IntI1

EN5165.T1

E. coli J53 Fox-azide

bla NDM-1

qnrB

aac(6′)-Ib

0.38

0.75

266

FIIK

 

IntI1

EN5165.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrB

aac(6′)-Ib

2

0.064

266

FIIK

 

IntI1

EN5166

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib bla CTX-M, SHV, OXA

4

> 32

266, 154

FIIK

–

IntI1

EN5166.T1

E. coli J53 Fox-azide

bla NDM-1

qnrB

aac(6′)-Ib

0.5

0.047

266

FIIK

–

IntI1

EN5166.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrB

bla CTX-M, OXA

aac(6′)-Ib

3

0.064

266

FIIK

 

IntI1

EN5170

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr, qnrB

aac(6′)-Ib, bla CTX-M, SHV, OXA

4

> 32

260, 200

FIIK

–

IntI1

EN5170.T1

E. coli J53 Fox-azide

bla NDM-1

qnrB

aac(6′)-Ib,

0.5

0.064

260

FIIK

–

IntI1

EN5170.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrB

aac(6′)-Ib

0.5

0.25

260

FIIK

 

IntI1

EN5173

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

bla CTX-M, SHV, OXA

aac(6′)-Ib

1.5

> 32

116, 90

FIIK,

–

IntI1

EN5173.T1

E. coli J53 Fox-azide

bla NDM-1

qnrB

aac(6′)-Ib

0.5

0.094

116

FIIK

–

IntI1

EN5173.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrB

aac(6′)-Ib

1

0.047

116

FIIK

 

IntI1

EN5174

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

bla CTX-M, SHV,OXA , armA

3

16

260, 7, 5, 4

FIIK, N, HIB-M

VagC/D

IntI1

EN5174.T1

E. coli J53 Fox-azide

bla NDM-1

aac(6′)-Ib-cr,qnrB

blaCTX-M, SHV,OXA, armA

3

6

260, 7, 5, 4

FIIK, N, HIB-M

Vagc/D

IntI1

EN5181

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrS

bla CTX-M, SHV, TEM,

2

14

220

FIIK, FII

PemK

–

EN5181.T1

E. coli J53 Fox-azide

bla NDM-1

qnrS

bla CTX-M, TEM

0.5

0.19

220

FIIK

–

–

EN5181.T2

E. coli J53 Cip-Azide

bla NDM-1

qnrS

bla CTX-M, TEM

0.75

0.19

220

FIIK

–

–

EN5185

Klebsiella pneumoniae

bla NDM-1

aac(6′)-Ib-cr,qnrB

bla CTX-M, SHV, OXA

aac(6′)-Ib

3

> 32

266, 154

FIIK

–

IntI1

EN5185.T1

E. coli J53 Fox-azide

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib

0.5

0.032

266

FIIK

–

IntI1

EN5185.T2

E. coli J53 Cip-Azide

bla NDM-1

aac(6′)-Ib-cr,qnrB

aac(6′)-Ib

1.5

0.19

266

FIIK

 -

IntI1

  1. MEM: meropenem, CIP: ciprofloxacin, (-): absent or untypable (in case of plasmid types), E. coli J53 Fox-azide or ‘.T1’ : transconjugants selected in cefoxitin (10μg/ml)-sodium azide (100μg/ml), ), E. coli J53 Cip-Azide or ‘.T2’ : transconjugants selected in ciprofloxacin (0.06 μg/ml)-sodium azide (100 μg/ml)
Back to article page

Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

Contact us