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Table 2 Univariate and multivariate Cox regression analyses for mortality of patients with CRAB-BSI

From: Comparison of Tigecycline or Cefoperazone/Sulbactam therapy for bloodstream infection due to Carbapenem-resistant Acinetobacter baumannii

 

Crude analysis

Adjusted analysis

HR (95% CI)

p value

HR (95% CI)

p value

> 60 years of age

1.382 (0.782–2.443)

0.265

..

..

Male sex

0.817 (0.512–1.303)

0.395

..

..

ICU admission

1.610 (0.852–3.041)

0.143

..

..

APACHE II score ≧20 at infection

2.346 (1.197–4.600)

0.013

2.530 (1.571–4.075)

0.000

PBS > 3 at infection

0.773 (0.418–1.429)

0.411

..

..

CPIS > 7 at infection

2.107 (1.253–3.545)

0.005

2.277 (1.424–3.640)

0.001

Sulbactam therapy

0.592 (0.344–1.020)

0.059

0.566 (0.342–0.940)

0.028

Underlying disease

 hypertension

1.562 (0.324–2.973)

0.040

0.762 (0.496–1.171)

0.214

 hepatitis/cirrhosis

1.004 (0.539–1.870)

0.991

..

..

 diabetes

1.188 (0.640–2.204)

0.586

..

..

 cardiac

1.188 (0.621–2.275)

0.602

..

..

 respiratory

0.922 (0.481–1.764)

0.805

..

..

 tumor

0.638 (0.224–1.817)

0.638

..

..

Comorbid conditions

 pulmonary infection

0.825 (0.514–1.324)

0.425

..

..

 septic shock

1.431 (0.859–2.384)

0.169

..

..

 respiratory failure

1.035 (0.600–1.784)

0.902

..

..

 MOF

2.671 (1.399–5.103)

0.003

2.268 (1.283–4.007)

0.005

 abdominal cavity infection

0.788 (0.331–1.877)

0.590

..

..

 stroke

2.412 (0.875–6.648)

0.089

1.789 (0.697–4.588)

0.226

 gastrointestinal bleeding

1.401 (0.537–3.653)

0.491

..

..

  1. Note: “..”P < 0.1 in the univariate analysis were entered into a multivariate analysis; P ≥ 0.1 in the univariate analysis were not entered into a multivariate analysis
  2. Abbreviations: CRAB-BSI, Acinetobacter baumannii bloodstream infection; HR, hazard ratio; CI, confidence interval;
  3. PBS Pitt Bacteraemia Score, CPIS Clinical Pulmonary Infection Score APACHE II score, acute physiology and chronic health evaluation II, ICU intensive care unit, MOF, multiple organ failure
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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