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Table 4 In vitro efficacy of DOX-SLN compared to free doxycycline against B. melitensis inside J774A.1 cells

From: Doxycycline-encapsulated solid lipid nanoparticles as promising tool against Brucella melitensis enclosed in macrophage: a pharmacodynamics study on J774A.1 cell line

Treatment Concentration (μg/ml)
100 50 25
Mean CFUs ± SEM Log CFUs reduction Mean CFUs ± SEM Log CFUs reduction Mean CFUs ± SEM Log CFUs reduction
Doxycycline 5.4 ± 0.03 0.9 5.6 ± 0.01 0.7 6.1 ± 0.04 0.2
DOX-SLN 3.5 ± 0.07 2.8 3.9 ± 0.03 2.4 3.6 ± 0.01 2.7
Free SLN (blank) 6.3 ± 0.01 0 6.3 ± 0.01 0 6.3 ± 0.01 0
Negative Control 6.3 ± 0.02 0 6.3 ± 0.02 0 6.3 ± 0.02 0