Table 4 In vitro efficacy of DOX-SLN compared to free doxycycline against B. melitensis inside J774A.1 cells
Treatment | Concentration (μg/ml) | |||||
|---|---|---|---|---|---|---|
100 | 50 | 25 | ||||
Mean CFUs ± SEM | Log CFUs reduction | Mean CFUs ± SEM | Log CFUs reduction | Mean CFUs ± SEM | Log CFUs reduction | |
Doxycycline | 5.4 ± 0.03 | 0.9 | 5.6 ± 0.01 | 0.7 | 6.1 ± 0.04 | 0.2 |
DOX-SLN | 3.5 ± 0.07 | 2.8 | 3.9 ± 0.03 | 2.4 | 3.6 ± 0.01 | 2.7 |
Free SLN (blank) | 6.3 ± 0.01 | 0 | 6.3 ± 0.01 | 0 | 6.3 ± 0.01 | 0 |
Negative Control | 6.3 ± 0.02 | 0 | 6.3 ± 0.02 | 0 | 6.3 ± 0.02 | 0 |