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Table 4 Adjusted analysis of the association between guideline adherence, 30-day readmission and length of stay

From: The association between adherence to national antibiotic guidelines and mortality, readmission and length of stay in hospital inpatients: results from a Norwegian multicentre, observational cohort study

 

All patients

30 day readmission

Length of stay

(N = 1670)

(N = 346)

(N = 1670)

P

(N = 1670)

(N = 1670)

P

n (%)

n (%)

OR (95%CI)

Mean (S.D)

Coeff. (95% C.I.)

Adherence to guideline

 No

623 (37.3)

140 (22.5)

1.00

 

7.3 (4.4)

  

 Yes

1047 (62.7)

206 (19.7)

0.87 (0.67, 1.14)

0.321

6.7 (4.1)

−0.47 (−1.02, 0.07)

0.081

Indication for antibiotic treatment

 LRTI

492 (29.5)

100 (20.3)

1.00

 

7.0 (4.3)

  

 COPD with LRTI

341 (20.4)

88 (25.8)

1.17 (0.80, 1.73)

0.421

6.6 (3.8)

−0.79 (−1.65, 0.08)

0.069

 Sepsis

275 (16.5)

46 (16.7)

0.81 (0.54, 1.21)

0.303

7.0 (3.9)

0.22 (−0.73, 1.18)

0.605

 SSTI

184 (11.0)

29 (15.8)

0.89 (0.62, 1.28)

0.522

6.2 (4.1)

−0.17 (−1.44, 1.10)

0.761

 GI-infection

75 (4.5)

18 (24.0)

1.26 (0.64, 2.51)

0.503

7.3 (4.2)

0.53 (− 0.75, 1.81)

0.363

 UTI

176 (10.5)

43 (24.4)

1.30 (0.85, 2.01)

0.229

7.1 (4.4)

0.10 (−0.74, 0.95)

0.781

 Other infections

127 (7.6)

22 (17.3)

0.78 (0.51, 1.18)

0.240

7.5 (5.1)

0.53 (−0.83, 1.89)

0.386

Charlson Comorbidity Index

 CCI = 0

656 (39.3)

97 (14.8)

1.00

 

6.3 (3.9)

  

 CCI = 1

562 (33.7)

117 (20.8)

1.35 (1.03, 1.76)

0.029

6.9 (4.0)

0.60 (−0.32, 1.53)

0.168

 CCI = 2

241 (14.4)

73 (30.3)

2.26 (1.46, 3.52)

< 0.001

7.3 (4.2)

0.87 (0.06, 1.68)

0.039

 CCI = 3

103 (6.2)

27 (26.2)

1.77 (1.12, 2.82)

0.015

7.7 (5.0)

1.30 (−0.79, 3.38)

0.185

 CCI = 4

49 (2.9)

16 (32.7)

2.55 (1.73, 3.76)

< 0.001

9.1 (5.4)

2.64 (− 0.42, 5.70)

0.081

 CCI > 4

59 (3.5)

16 (27.1)

1.88 (0.89, 3.95)

0.098

9.1 (5.2)

2.42 (1.15, 3.69)

0.003

Age

  < =45

250 (15.0)

37 (14.8)

1.00

 

5.7 (4.1)

  

 46–65

387 (23.2)

75 (19.4)

1.07 (0.71, 1.62)

0.743

6.6 (4.0)

0.74 (0.45, 1.03)

0.001

 66–85

779 (46.7)

175 (22.5)

1.15 (0.70, 1.90)

0.576

7.3 (4.3)

1.20 (0.58, 1.83)

0.002

  > 85

254 (15.2)

59 (23.2)

1.24 (0.62, 2.49)

0.549

7.2 (4.3)

1.00 (−0.19, 2.18)

0.087

Sex

 Male

856 (51.3)

182 (21.3)

1.00

 

6.9 (4.3)

  

 Female

814 (48.7)

164 (20.2)

0.94 (0.81, 1.09)

0.411

6.9 (4.1)

0.02 (−0.64, 0.69)

0.942

Admitted from institution

 No

1441 (86.3)

301 (20.9)

1.00

 

6.8 (4.2)

  

 Yes

229 (13.7)

45 (19.7)

0.85 (0.62, 1.16)

0.307

7.2 (4.5)

0.02 (−0.53, 0.57)

0.938

Week of admissiona

  

0.98 (0.96, 1.00)

0.040

 

−0.05 (− 0.09, − 0.002)

0.044

  1. aAdjustment for seasonality was performed by using the week of admission as adjustment variable
  2. All variables are included in adjusted analysis. 30-day readmission and length of stay was analysed using multivariate logistic- and linear regression, respectively with adjustment for clustering at individual sites. P-values in boldface are statistically significant (<0.05)