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Table 1 Phenotypic profiles and Colistin, PMB MICs of fungal strains tested in this study

From: In vitro polymyxin activity against clinical multidrug-resistant fungi

  Clinical samples MICs (μg/mL)
Anid Mica Caspo Flu 5-Fc Posa Itra Vorico AB Isavu Ct PMB
Candida krusei ATCC 6258 / 0.06 0.12 0.25 32 8 0.25 0.12 0.25 1 ND 64 32
Candida parapsilosis ATCC 22019 / 0.5 0.5 0.12 1 0.12 0.03 0.008 0.03 0.5 ND 64 16
Rhodotorula mucilaginosa Endobucal > 8 > 8 > 8 128 0.06 1 0.5 2 1 ND 32 16
Cryptococcus neoformans Blood > 8 > 8 > 8 2 1 0.03 0.12 0.03 0.5 ND 32 16
Candida albicans H5 CSF 0.015 0.03 0.05 16 1 0.5 0.5 0.25 0.25 ND 128 128
Candida albicans H6 Nails 0.06 0.03 0.12 > 256 0.12 > 8 32 256 1 ND 128 64
Aspergillus fumigatus ATCC 204205 / ND ND ND ND ND 0.008 0.015 0.12 2 ND >  256 >  256
Aspergillus flavus ATCC 204304 / ND ND ND ND ND 0.06 0.06 1 4 ND > 256 >  256
Aspergillus calidoustus Bronchial aspiration ND ND ND ND ND 1 6 4 4 0.25 256 128
Fusarium oxysporumY5 Nails ND ND ND ND ND > 32 > 32 2 4 > 32 64 16
Fusarium solani Y6 Ocular sample ND ND ND ND ND >  32 > 32 > 32 > 32 >  32 64 16
Rhizopus oryzae Y9 Sinus biopsy ND ND ND ND ND >  32 > 32 > 32 > 32 > 32 128 64
Lomentospora prolificans Y8 Blood ND ND ND ND ND > 32 64 > 32 > 32 > 32 32 16
Scedosporium apiospermum F2 Bronchial aspiration ND ND ND ND ND 2 0.75 > 32 4 ND 16 16
Lichtheimia corymbifera ST87 Eyes ND ND ND ND ND 2 2 > 32 2 2 32 32
  1. Anid - Anidulafungin; Mica - Micafungin; Casp - Caspofungin; Flu - Fluconazole; 5-Fc - 5-Flurocytosin; Pos - Posaconazol, Itra - Itraconazole; Vori - Voriconazole; AB - Amphotericin B; Isavu – Isavuconazole; Ct – Colistin; PMB- Polymyxin B; MIC - Minimum Inhibitory Concentration; ND: Not Done