Distribution of blaCTX − M, blaTEM, blaSHV and blaOXA genes in Extended-spectrum-β-lactamase-producing Clinical isolates: A three-year multi-center study from Lahore, Pakistan

Table 3 Minimum Inhibitory Concentration (MIC) of applied antibiotics along with clavulanic acid

Ceftazidime/ceftazidime with clavulanic acid MIC^a (μg/ml)
MIC ratio	> 32/> 4 (ND)^a	> 32/0.064 = 500	> 32/0.125 = 256	24/0.19 = 126	16/0.38 = 42.1	4/0.25 = 16
E. coli (n = 321)	13 (4%)	241 (75%)	39 (12%)	19 (6%)	3 (1%)	6 (2%)
Klebsiella spp. (n = 124)	2 (1.8%)	99 (80%)	10 (8.3%)	6 (4.6%)	7 (5.5%)	0 (0%)
Pseudomonas spp. (n = 24)	5 (21%)	17 (72%)	2 (8.3%)	0 (0%)	0 (0%)	0 (0%)
Enterobacter spp. (n = 20)	2 (10%)	15 (75%)	2 (10%)	0 (0%)	1 (5%)	0 (0%)
Acinetobacter spp. (n = 8)	6 (75%)	2 (25%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Cefotaxime/cefotaxime with clavulanic acid MIC (μg/ml)
MIC ratio	> 16/> 1 (ND)^b	> 16/0.016 = 1000	12/0.023 = 521	3/0.023 = 130	8/0.125 = 64	4/0.094 = 42.5
E. coli (n = 321)	17 (5.4%)	206 (64%)	58 (18%)	17 (5.4%)	12 (3.7%)	11 (3.4%)
Klebsiella spp. (n = 124)	2 (1.8%)	85 (69%)	19 (15%)	9 (7.4%)	7 (5.5%)	2 (1.8%)
Pseudomonas spp. (n = 24)	2 (8.3%)	15 (63%)	0 (0%)	0 (0%)	2 (8.3%)	1 (4%)
Enterobacter spp. (n = 20)	1 (5%)	2 (10%)	0 (0%)	0 (0%)	0 (0%)	17 (85%)
Acinetobacter spp. (n = 8)	8 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)

ISSN: 2047-2994