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Table 1 Demographic and clinical characteristics of CCRT patients by group

From: Appropriateness of antimicrobial use among septic patients managed by the critical care response team: an opportunity for improvement through de-escalation

 Cases
N = 157
Control
N = 158
Total
N = 315
p-value
Age (years)
 Mean ± SD58.5 ± 21.463.6 ± 19.061.1 ± 20.40.024
  < 5052 (33.3%)28 (17.7%)80 (25.5%)0.004
 50–6434 (21.8%)57 (36.1%)91 (29.0%) 
 65–8455 (35.3%)57 (36.1%)112 (35.7%) 
  ≥ 8515 (9.6%)16 (10.1%)31 (9.9%) 
Gender
 Male87 (55.4%)85 (53.8%)172 (54.6%)0.773
 Female70 (44.6%)73 (46.2%)143 (45.4%) 
Body mass index
 Mean ± SD27.1 ± 7.827.1 ± 7.727.1 ± 7.8> 0.99
 Non-obese103 (65.6%)107 (67.7%)210 (66.7%)0.69
 Obese54 (34.4%)51 (32.3%)105 (33.3%) 
Service
 Medical79 (50.3%)98 (62.0%)177 (56.2%)0.037
 Surgical36 (22.9%)32 (20.3%)68 (21.6%) 
 Hepatobiliary4 (2.5%)6 (3.8%)10 (3.2%) 
 Oncology27 (17.2%)17 (10.8%)44 (14.0%) 
 Obstetrics and gynecology0 (0.0%)2 (1.3%)2 (0.6%) 
 Others11 (7.0%)3 (1.9%)14 (4.4%) 
CCRT triggers
 Threatened airway0 (0.0%)1 (0.6%)1 (0.3%)> 0.99
 Respiratory rate < 8 or > 30 per minute45 (28.7%)48 (30.4%)93 (29.5%)0.738
 Oxygen saturation < 90%21 (13.4%)26 (16.5%)47 (14.9%)0.443
 Systolic blood pressure < 90 mmHg69 (43.9%)8 (5.1%)77 (24.4%)< 0.001
 Systolic blood pressure > 200 mmHg1 (0.6%)6 (3.8%)7 (2.2%)0.121
 Heart rate < 40 or > 130 beats per minute36 (22.9%)30 (19.0%)66 (21.0%)0.39
 Glasgow coma score drop ≥217 (10.8%)37 (23.4%)54 (17.1%)0.003
 Urine output ≤100 ml per 4 h8 (5.1%)6 (3.8%)14 (4.4%)0.576
 Serious concern by treating team2 (1.3%)11 (7.0%)13 (4.1%)0.011
 Others/unclear15 (9.6%)14 (8.9%)29 (9.2%)0.831
Important times (median & IQR)
 Length of stay (days)14 (9–28)16 (11–30)15 (10–30)0.468
 Days before CCRT activation14 (4–44)7 (2–23)10 (2–33)< 0.001
 Minutes from CCRT activation to AM order33 (21–72)46 (24–65)36 (22–72)0.243
 Minutes from AM order to AM use73 (37–115)82 (48–150)74 (38–120)0.229
  1. Abbreviation; CCRT, critical care response team; AM, antimicrobial; SD, standard deviation; IQR, interquartile range