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Table 1 Demographic and clinical characteristics of CCRT patients by group

From: Appropriateness of antimicrobial use among septic patients managed by the critical care response team: an opportunity for improvement through de-escalation

 

Cases

N = 157

Control

N = 158

Total

N = 315

p-value

Age (years)

 Mean ± SD

58.5 ± 21.4

63.6 ± 19.0

61.1 ± 20.4

0.024

  < 50

52 (33.3%)

28 (17.7%)

80 (25.5%)

0.004

 50–64

34 (21.8%)

57 (36.1%)

91 (29.0%)

 

 65–84

55 (35.3%)

57 (36.1%)

112 (35.7%)

 

  ≥ 85

15 (9.6%)

16 (10.1%)

31 (9.9%)

 

Gender

 Male

87 (55.4%)

85 (53.8%)

172 (54.6%)

0.773

 Female

70 (44.6%)

73 (46.2%)

143 (45.4%)

 

Body mass index

 Mean ± SD

27.1 ± 7.8

27.1 ± 7.7

27.1 ± 7.8

> 0.99

 Non-obese

103 (65.6%)

107 (67.7%)

210 (66.7%)

0.69

 Obese

54 (34.4%)

51 (32.3%)

105 (33.3%)

 

Service

 Medical

79 (50.3%)

98 (62.0%)

177 (56.2%)

0.037

 Surgical

36 (22.9%)

32 (20.3%)

68 (21.6%)

 

 Hepatobiliary

4 (2.5%)

6 (3.8%)

10 (3.2%)

 

 Oncology

27 (17.2%)

17 (10.8%)

44 (14.0%)

 

 Obstetrics and gynecology

0 (0.0%)

2 (1.3%)

2 (0.6%)

 

 Others

11 (7.0%)

3 (1.9%)

14 (4.4%)

 

CCRT triggers

 Threatened airway

0 (0.0%)

1 (0.6%)

1 (0.3%)

> 0.99

 Respiratory rate < 8 or > 30 per minute

45 (28.7%)

48 (30.4%)

93 (29.5%)

0.738

 Oxygen saturation < 90%

21 (13.4%)

26 (16.5%)

47 (14.9%)

0.443

 Systolic blood pressure < 90 mmHg

69 (43.9%)

8 (5.1%)

77 (24.4%)

< 0.001

 Systolic blood pressure > 200 mmHg

1 (0.6%)

6 (3.8%)

7 (2.2%)

0.121

 Heart rate < 40 or > 130 beats per minute

36 (22.9%)

30 (19.0%)

66 (21.0%)

0.39

 Glasgow coma score drop ≥2

17 (10.8%)

37 (23.4%)

54 (17.1%)

0.003

 Urine output ≤100 ml per 4 h

8 (5.1%)

6 (3.8%)

14 (4.4%)

0.576

 Serious concern by treating team

2 (1.3%)

11 (7.0%)

13 (4.1%)

0.011

 Others/unclear

15 (9.6%)

14 (8.9%)

29 (9.2%)

0.831

Important times (median & IQR)

 Length of stay (days)

14 (9–28)

16 (11–30)

15 (10–30)

0.468

 Days before CCRT activation

14 (4–44)

7 (2–23)

10 (2–33)

< 0.001

 Minutes from CCRT activation to AM order

33 (21–72)

46 (24–65)

36 (22–72)

0.243

 Minutes from AM order to AM use

73 (37–115)

82 (48–150)

74 (38–120)

0.229

  1. Abbreviation; CCRT, critical care response team; AM, antimicrobial; SD, standard deviation; IQR, interquartile range