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Table 4 Appropriateness of antimicrobial use at the fourth day of CCRT activation by group

From: Appropriateness of antimicrobial use among septic patients managed by the critical care response team: an opportunity for improvement through de-escalation

 Cases
N = 157
Control
N = 158
Total
N = 315
p-value
Appropriateness of all antimicrobials
 Overall171 (50.7%)118 (59.6%)289 (54.0%)0.047
 Choice180 (53.4%)121 (61.1%)301 (56.3%)0.083
 Dose328 (97.6%)196 (99.0%)524 (98.1%)0.433
 Duration179 (53.1%)120 (60.6%)299 (55.9%)0.092
 Route336 (99.7%)198 (100.0%)534 (99.8%)> 0.99
Overall appropriateness of individual antimicrobials
 Meropenem14 (15.2%)8 (20.0%)22 (16.7%)0.498
 Vancomycin33 (63.5%)14 (58.3%)47 (61.8%)0.831
 Piperacillin-tazobactam29 (87.9%)32 (86.5%)61 (87.1%)> 0.99
 Caspofungin6 (35.3%)5 (71.4%)11 (45.8%)0.245
 Colistin9 (75.0%)9 (81.8%)18 (78.3%)> 0.99
 Linezolid9 (52.9%)4 (80.0%)13 (59.1%)0.587
 Tigecycline6 (46.2%)3 (75.0%)9 (52.9%)0.671
 Anidulafungin5 (50.0%)0 (0.0%)5 (33.3%)0.168
 Ceftriaxone4 (66.7%)7 (77.8%)11 (73.3%)> 0.99
 Ciprofloxacin5 (83.3%)5 (55.6%)10 (66.7%)0.587
 Imipenem1 (25.0%)2 (25.0%)3 (25.0%)> 0.99
 Others50 (66.7%)29 (74.4%)79 (69.3%)0.398
Post-CCRT de-escalation of individual antimicrobials by primary team
 Meropenem28 (33.3%)12 (33.3%)40 (33.3%)> 0.99
 Vancomycin39 (54.9%)12 (54.5%)51 (54.8%)0.975
 Piperacillin-tazobactam7 (25.0%)8 (40.0%)15 (31.3%)0.269
 Caspofungin3 (33.3%)2 (100.0%)5 (45.5%)0.182
 Colistin3 (42.9%)3 (50.0%)6 (46.2%)> 0.99
 Linezolid5 (38.5%)0 (0.0%)5 (29.4%)0.261
 Tigecycline1 (25.0%)3 (60.0%)4 (44.4%)0.524
 Anidulafungin2 (50.0%)1 (50.0%)3 (50.0%)> 0.99
 Ceftriaxone2 (50.0%)7 (77.8%)9 (69.2%)0.530
 Ciprofloxacin1 (33.3%)2 (33.3%)3 (33.3%)> 0.99
 Imipenem3 (42.9%)4 (100.0%)7 (63.6%)0.194
 Others46 (70.8%)26 (66.7%)72 (69.2%)0.867
 Overall140 (46.8%)80 (51.6%)220 (48.5%)0.333