Table 4 Appropriateness of antimicrobial use at the fourth day of CCRT activation by group
Cases N = 157 | Control N = 158 | Total N = 315 | p-value | |
|---|---|---|---|---|
Appropriateness of all antimicrobials | ||||
Overall | 171 (50.7%) | 118 (59.6%) | 289 (54.0%) | 0.047 |
Choice | 180 (53.4%) | 121 (61.1%) | 301 (56.3%) | 0.083 |
Dose | 328 (97.6%) | 196 (99.0%) | 524 (98.1%) | 0.433 |
Duration | 179 (53.1%) | 120 (60.6%) | 299 (55.9%) | 0.092 |
Route | 336 (99.7%) | 198 (100.0%) | 534 (99.8%) | > 0.99 |
Overall appropriateness of individual antimicrobials | ||||
Meropenem | 14 (15.2%) | 8 (20.0%) | 22 (16.7%) | 0.498 |
Vancomycin | 33 (63.5%) | 14 (58.3%) | 47 (61.8%) | 0.831 |
Piperacillin-tazobactam | 29 (87.9%) | 32 (86.5%) | 61 (87.1%) | > 0.99 |
Caspofungin | 6 (35.3%) | 5 (71.4%) | 11 (45.8%) | 0.245 |
Colistin | 9 (75.0%) | 9 (81.8%) | 18 (78.3%) | > 0.99 |
Linezolid | 9 (52.9%) | 4 (80.0%) | 13 (59.1%) | 0.587 |
Tigecycline | 6 (46.2%) | 3 (75.0%) | 9 (52.9%) | 0.671 |
Anidulafungin | 5 (50.0%) | 0 (0.0%) | 5 (33.3%) | 0.168 |
Ceftriaxone | 4 (66.7%) | 7 (77.8%) | 11 (73.3%) | > 0.99 |
Ciprofloxacin | 5 (83.3%) | 5 (55.6%) | 10 (66.7%) | 0.587 |
Imipenem | 1 (25.0%) | 2 (25.0%) | 3 (25.0%) | > 0.99 |
Others | 50 (66.7%) | 29 (74.4%) | 79 (69.3%) | 0.398 |
Post-CCRT de-escalation of individual antimicrobials by primary team | ||||
Meropenem | 28 (33.3%) | 12 (33.3%) | 40 (33.3%) | > 0.99 |
Vancomycin | 39 (54.9%) | 12 (54.5%) | 51 (54.8%) | 0.975 |
Piperacillin-tazobactam | 7 (25.0%) | 8 (40.0%) | 15 (31.3%) | 0.269 |
Caspofungin | 3 (33.3%) | 2 (100.0%) | 5 (45.5%) | 0.182 |
Colistin | 3 (42.9%) | 3 (50.0%) | 6 (46.2%) | > 0.99 |
Linezolid | 5 (38.5%) | 0 (0.0%) | 5 (29.4%) | 0.261 |
Tigecycline | 1 (25.0%) | 3 (60.0%) | 4 (44.4%) | 0.524 |
Anidulafungin | 2 (50.0%) | 1 (50.0%) | 3 (50.0%) | > 0.99 |
Ceftriaxone | 2 (50.0%) | 7 (77.8%) | 9 (69.2%) | 0.530 |
Ciprofloxacin | 1 (33.3%) | 2 (33.3%) | 3 (33.3%) | > 0.99 |
Imipenem | 3 (42.9%) | 4 (100.0%) | 7 (63.6%) | 0.194 |
Others | 46 (70.8%) | 26 (66.7%) | 72 (69.2%) | 0.867 |
Overall | 140 (46.8%) | 80 (51.6%) | 220 (48.5%) | 0.333 |