Table 1 Definition criteria and antibiotic panel for Enterobacterales (Escherichia coli, Klebsiella pneumoniae and Enterobacter sp.)
From: The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods
| Antimicrobial category | ECDC-MDR | KRINKO-3MRGN | KRINKO-4MRGN | UHZ-MDR |
|---|---|---|---|---|
| Antipseudomonal penicillins | Piperacillin/ tazobactam or ticarcillin/ clavulanic acid | Piperacillin a) | Piperacillin a) | Piperacillin/ tazobactam |
| Extended spectrum cephalosporins | Cefotaxime or ceftriaxone or ceftazidime or cefepime | Cefotaxime b) or ceftazidime | Cefotaxime b) or ceftazidime | Ceftriaxone and ceftazidime and cefepime |
| Carbapenems | Ertapenem or imipenem or meropenem or doripenem | Imipenem or meropenem | Imipenem or meropenem | ≥ 2 of: Ertapenem, imipenem, meropenem |
| Quinolones | Ciprofloxacin | Ciprofloxacin | Ciprofloxacin | Ciprofloxacin and levofloxacin |
| Aminoglycosides | Amikacin or gentamicin or tobramycin or netilmicin | ≥2 of: Amikacin, gentamicin, tobramycin | ||
| Monobactams | Aztreonam | |||
| Phosphonic acids | Fosfomycin | |||
| non-extended spectrum cepholosporins | Cefazolin c) or cefuroxime | |||
| anti-MRSA cephalosporins e) | Ceftaroline | |||
| Cephamycins | Cefoxitin c) or Cefotetan c) | |||
| Folate pathway inhibitors | Trimethoprim/ sulphamethoxazol | |||
| Glycylcyclines | Tigecycline | |||
| Penicillins | Ampicillin c) d) | |||
| Penicillins plus beta-lactamase-inhibitors | Amoxicillin/ clavulanic acid c) or ampicillin/ sulbactam c) | |||
| Phenicols | Chloramphenicol | |||
| Polymyxins | Colistin or polymyxin B | |||
| Tetracyclines | Tetracycline or doxycycline or minocycline | |||
| Definition of MDR | Resistant to ≥3 categories | Resistant to antipseudomonal penicillin and cephalosporin-group and quinolone and susceptible to carbapenems | Resistant to all 4 categories or if a carbapenem is resistant all Enterobacterales are interpreted as 4MRGN or Enterobacterales with carbapenemase production | Resistant to 3 out of 5 categories or ESBL-producing Enterobacterales (except E.coli) or Enterobacterales with carbapenemase production |