Table 1 Definition criteria and antibiotic panel for Enterobacterales (Escherichia coli, Klebsiella pneumoniae and Enterobacter sp.)

Antipseudomonal penicillins

Piperacillin/ tazobactam or ticarcillin/ clavulanic acid

Piperacillin ^a)

Piperacillin ^a)

Piperacillin/ tazobactam

Extended spectrum cephalosporins

Cefotaxime or ceftriaxone or ceftazidime or cefepime

Cefotaxime ^b) or ceftazidime

Cefotaxime ^b) or ceftazidime

Ceftriaxone and ceftazidime and cefepime

Carbapenems

Ertapenem or imipenem or meropenem or doripenem

Imipenem or meropenem

Imipenem or meropenem

≥ 2 of: Ertapenem, imipenem, meropenem

Quinolones

Ciprofloxacin

Ciprofloxacin

Ciprofloxacin

Ciprofloxacin and levofloxacin

Aminoglycosides

Amikacin or gentamicin or tobramycin or netilmicin

≥2 of: Amikacin, gentamicin, tobramycin

Monobactams

Aztreonam

Phosphonic acids

Fosfomycin

non-extended spectrum cepholosporins

Cefazolin ^c) or cefuroxime

anti-MRSA cephalosporins ^e)

Ceftaroline

Cephamycins

Cefoxitin ^c) or Cefotetan ^c)

Folate pathway inhibitors

Trimethoprim/ sulphamethoxazol

Glycylcyclines

Tigecycline

Penicillins

Ampicillin ^{c) d)}

Penicillins plus beta-lactamase-inhibitors

Amoxicillin/ clavulanic acid ^c) or ampicillin/ sulbactam ^c)

Phenicols

Chloramphenicol

Polymyxins

Colistin or polymyxin B

Tetracyclines

Tetracycline or doxycycline or minocycline

Definition of MDR

Resistant to ≥3 categories

Resistant to antipseudomonal penicillin and cephalosporin-group and quinolone and susceptible to carbapenems

Resistant to all 4 categories or if a carbapenem is resistant all Enterobacterales are interpreted as 4MRGN or Enterobacterales with carbapenemase production

Resistant to 3 out of 5 categories or ESBL-producing Enterobacterales (except E.coli) or Enterobacterales with carbapenemase production