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Table 2 Definition criteria and antibiotic panel for Pseudomonas aeruginosa

From: The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods

Antimicrobial categoryECDC-MDRKRINKO-3MRGNKRINKO-4MRGNUHZ-MDR
Antipseudomonal penicillinsPiperacillin/ tazobactam or ticarcillin/ clavulanic acidPiperacillin a)Piperacillin a)Piperacillin/ tazobactam
Extended spectrum cephalosporinsCeftazidime or cefepimeCeftazidime and cefepimeCeftazidime and cefepimeCeftazidime and cefepime
CarbapenemsImipenem or meropenem or doripenemImipenem and meropenemImipenem and meropenemImipenem or meropenem
QuinolonesCiprofloxacin or levofloxacinCiprofloxacinCiprofloxacinCiprofloxacin and levofloxacin
AminoglycosidesAmikacin or gentamicin or tobramycin or netilmicin  ≥2 of: Amikacin, gentamicin, tobramycin
MonobactamsAztreonam   
Phosphonic acidsFosfomycin   
PolymyxinsColistin or polymyxin B   
Definition of MDRResistant to ≥3 categoriesResistant to 3 out of 4 categoriesResistant to all 4 categoriesResistant to 3 out of 5 categories
  1. Abbreviations: ECDC-MDR Multidrug resistance according to the European Centre for Disease Prevention and Control, KRINKO-3MRGN Multidrug resistance to three antibiotic categories according to the German Commission of Hospital Hygiene and Infection Prevention, KRINKO-4MRGN Multidrug resistance to four antibiotic categories according to the German Commission of Hospital Hygiene and Infection Prevention, MDR multidrug resistant, UHZ-MDR multidrug resistance according to University Hospital Zurich guidelines
  2. a) not tested in UHZ, replaced by piperacillin/tazobactam
  3. Italic font: not tested in UHZ or only tested by MIC under special circumstances