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Table 3 Definition criteria and antibiotic panel for Acinetobacter baumannii complex

From: The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods

Antimicrobial categoryECDC-MDRKRINKO-3MRGNKRINKO-4MRGNUHZ-MDR
Antipseudomonal penicillinsPiperacillin/ tazobactam or ticarcillin/ clavulanic acidPiperacillin a)Piperacillin a)Piperacillin/ tazobactam
Extended spectrum cephalosporinsCefotaxime or ceftriaxone or ceftazidime or cefepimeCefotaxime b) or ceftazidimeCefotaxime b) or ceftazidimeCeftazidime and cefepime
CarbapenemsImipenem or meropenem or doripenemImipenem or meropenemImipenem or meropenemImipenem or meropenem
QuinolonesCiprofloxacin or levofloxacinCiprofloxacinCiprofloxacinCiprofloxacin and levofloxacin
AminoglycosidesAmikacin or gentamicin or tobramycin or netilmicin  ≥2 of: Amikacin, gentamicin, tobramycin
Folate pathway inhibitorsTrimethoprim/ sulphamethoxazol   
Penicillins plus beta-lactamase-inhibitorsAmpicillin/ sulbactam   
PolymyxinsColistin or polymyxin B   
TetracyclinesTetracycline or doxycycline or minocycline   
Definition of MDRResistant to ≥3 categoriesResistant to antipseudomonal penicillin and cephalosporin-group and quinolone and susceptible to carbapenemsResistant to all 4 categories or If a carbapenem is resistant all Acinetobacter are interpreted as 4MRGN or Acinetobacter with carbapenemase productionResistant to 3 out of 5 categories
  1. Abbreviations: ECDC-MDR Multidrug resistance according to the European Centre for Disease Prevention and Control, KRINKO-3MRGN Multidrug resistance to three antibiotic categories according to the German Commission of Hospital Hygiene and Infection Prevention, KRINKO-4MRGN Multidrug resistance to four antibiotic categories according to the German Commission of Hospital Hygiene and Infection Prevention, MDR Multidrug resistant, UHZ-MDR multidrug resistance according to University Hospital Zurich guidelines
  2. a) as piperacillin/tazobactam and not piperacillin was tested: Resistance to ceftriaxone and/or ceftazidime was interpreted as resistance to piperacillin (15)
  3. b) as cefotaxime was not tested, ceftazidime replaces cefotaxime
  4. Italic font: not tested in UHZ or only tested by MIC under special circumstances