VRE-Related Parameters
|
Beta, basic reproductive number
|
1.32
|
1.03–1.46
|
Full
|
0.12
|
Gamma
|
Satilmis 2016 [13]
|
VRE prevalence, general
|
0.023
|
0–0.18
|
Full
|
0.001
|
Beta
|
Williams 2015 [14]
|
VRE prevalence, high-risk patients
|
0.092
|
0–0.36
|
Plausible
|
0.002
|
Beta
|
Conly 2001 [15]
|
LOS | without VRE infection, days
|
3
|
1.0–6.0
|
Full (IQR)
|
0.38
|
Gamma
|
Johnstone 2018 [2]
|
LOS | other VRE infection, days
|
6
|
1.0–6.0
|
Full (IQR)
|
0.77
|
Gamma
|
Assumption; Johnstone 2018 [2]
|
LOS | VRE-bacteremia, days
|
39
|
22.0–81.0
|
Full (IQR)
|
4.97
|
Gamma
|
Johnstone 2018 [2]
|
Screening Parameters
|
Sensitivity, rectal swab
|
0.991
|
0.95–1.00
|
Full
|
0.02
|
Beta
|
Stamper 2010 [16]
|
Specificity, rectal swab
|
0.949
|
0.92–0.97
|
Full
|
0.01
|
Beta
|
Stamper 2010 [16]
|
Effectiveness of isolation
|
1.00
|
0.75–1.00
|
Plausible
|
–
| |
Assumption
|
Discount rate, annual
|
0.015
|
0–0.03
|
Full
|
–
|
–
|
CADTH 2017 [11]
|
Patient Parameters and Transition Probabilities
|
Average age high-risk, years
|
61
|
–
|
–
|
1.15
|
Normal
|
Johnstone 2018 [2]
|
Probability infected | colonised
|
0.025
|
0.018–0.031
|
Plausible
|
0.003
|
Beta
|
Williams 2015 [14]
|
Probability bacteremia | infected
|
0.155
|
0.12–0.19
|
Plausible
|
0.02
|
Beta
|
Saunders 2004 [17]
|
Odds ratio bacteremia | infected, high-risk
|
1.55
|
0.56–4.29
|
Full
|
1.68
|
Lognormal
|
Johnstone 2018 [2]
|
Average days of treatment for BSI
|
14
|
11–18
|
Plausible
|
1.79
|
Gamma
|
Daneman 2016 [18]
|
Average days of treatment for other infections
|
7
|
5–9
|
Plausible
|
0.89
|
Gamma
|
Daneman 2016 [18]
|
Probability of death from VRE bacteremia, average, 14 days
|
0.37
|
0.27–0.46
|
Plausible
|
0.05
|
Beta
|
Billington 2014 [19]
|
Probability of death from VRE bacteremia, high-risk, 14 days
|
0.46
|
0.35–0.58
|
Plausible
|
0.06
|
Beta
|
Linden 1996 [20]
|
Number of room visits by all HCW, per day
|
24
|
18–30
|
Plausible
|
3.06
|
Normal
|
Assumption
|
Costs
|
Rectal swab screen
|
3.13
|
2.35–3.91
|
Plausible
|
0.40
|
Gamma
|
Muto 2002 [9]
|
Culture, positive test
|
21.36
|
16.02–26.7
|
Plausible
|
2.72
|
Gamma
|
Muto 2002 [9]
|
Culture, negative test
|
8.97
|
6.73–11.21
|
Plausible
|
1.14
|
Gamma
|
Muto 2002 [9]
|
PPE, per room visit
|
2.10
|
1.58–2.63
|
Plausible
|
0.27
|
Gamma
|
Muto 2002 [9]
|
Nurse time, per test
|
7.12
|
5.34–8.9
|
Plausible
|
0.91
|
Gamma
|
Muto 2002 [9]
|
Private room, daily
|
290
|
245–410
|
Full
|
–
|
–
|
St. Joseph’s Hospital 2017 [21]
|
Antibiotics, bacteremia, daily
|
524.22
|
393.17–655.28
|
Plausible
|
66.87
|
Gamma
|
Nasr 2011 [22]
|
Antibiotics, other infections, daily
|
35.8
|
26.85–44.75
|
Plausible
|
4.57
|
Gamma
|
Nasr 2011 [22]
|
Utilities
|
VRE bacteremia
|
0.56
|
0.51–0.61
|
Full
|
0.023
|
Beta
|
Lee 2010 [23]
|
Other local infections (UTI)
|
0.60
|
0.58–0.62
|
Full
|
0.01
|
Beta
|
Haran 2005 [24]
|
Inpatient
|
0.642
|
0.54–0.74
|
Full
|
0.05
|
Beta
|
Tengs, 2000 [25]; Selai 1995 [26]
|
Mild depression, no treatment
|
0.88
|
0.84–0.92
|
Full
|
0.02
|
Beta
|
Revicki 1997 [27]
|
Well, chronic conditions, recovered from previous VRE-related infection
|
0.86
|
0.34–0.89
|
Full
|
0.15
|
Beta
|
Mittmann 1999 [28]
|
Well, chronic conditions, no previous VRE-related infection
|
0.93
|
0.88–0.94
|
Full
|
0.083
|
Beta
|
Mittmann 1999 [28]
|