Genomic characterization of Citrobacter freundii strains coproducing OXA-48 and VIM-1 carbapenemase enzymes isolated in leukemic patient in Spain

Table 2 Analysis of the three C. freundii strains isolated from fecal samples of leukemic patients

Strain	Genome size (bp)	GC%	ST	MIC IPM (mg/L)	Sensitive phenotype	Resistance phenotype	Genome composition/ size (bp)	ARGs	Plasmid type	Accession number
CF_154	5,444,819	51,5	169	≥32	DOX, CST, FOF, NIT	AMX, AMC, TZP, CEF, FEP, CRO, ERT, IPM, CIP, AMK, GEN, SXT.	CF154_Chromosome/ 5,143,118	bla_CMY-81, bla_OXA-48, bla_TEM-150, aac3-IId, aph3-Ia, strA, strB, qnrB38, sulII.	/	CP038653
							Plasmid_1 (p154_1)/ 296,117	bla_CTX-M-9, bla_SHV-12, bla_VIM-1, aac6-Ib-cr, aadA1-pm, aadA2, aadB, qnr-A1, catA1, sulI, dfr16.	IncHI2	CP038654
							Plasmid_2 (p154_2)/ 5584	/	ColRNAI_1	CP038655
CF_565	5,471,065	51,5	169	≥32	DOX, CST, FOF, NIT	AMX, AMC, TZP, CEF, FEP, CRO, ERT, IPM, CIP, AMK, GEN, SXT.	CF565_Chromosome/ 5,207,876	bla_CMY-81, bla_OXA-48, bla_TEM-150, aac3-IId, aph3-Ia, strA, strB, qnrB38, sulII.	/	CP038656
CF_565	5,471,065	51,5	169	≥32	DOX, CST, FOF, NIT	AMX, AMC, TZP, CEF, FEP, CRO, ERT, IPM, CIP, AMK, GEN, SXT.	Plasmid_1 (p565_1)/ 263,189	bla_CTX-M-9, bla_SHV-12, bla_VIM-1, aac6-Ib-cr, aadA1-pm, aadA2, qnr-A1, catA1, sulI, dfr16.	IncHI2	CP038657
CF_680	5,557,664	51,4	169	≥32	DOX, CST, FOF, NIT	AMX, AMC, TZP, CEF, FEP, CRO, ERT, IPM, CIP, AMK, GEN, SXT.	CF680_Chromosome/ 5,167,642	bla_CMY-81, bla_OXA-48, bla_TEM-150, aac3-IId, aph3-Ia, strA, strB, qnrB38, sulII.	/	CP038658
							Plasmid_1 (p680_1)/ 385,971	bla_CTX-M-9, bla_OXA-9, bla_SHV-12, bla_TEM-150, bla_VIM-1, aac6-Ib-cr, aadA1-pm, aadA2, aadB, qnr-A1, catA1, sulI, dfr16.	IncHI2	CP038659
							Plasmid_2 (p680_2)/ 4051	/	ColRNAI_1	CP038660

AMX Amoxicillin, AMC Amoxicillin/clavulanic acid, TZP Piperacillin + Tazobactam, CEF Cephalothin, FEP Cefepime, CRO Ceftriaxone, ERT Ertapenem, IPM Imipenem, CIP Ciprofloxacin, AMK Amikacin, GEN Gentamicin, DOX Doxycycline, CST; Colistin, FOF Fosfomycin, NIT Nitrofurantoin, SXT Sulfamethoxazole/trimethoprim, MIC Minimum Inhibitory Concentration, ARGs Antibiotic resistance genes, ST Sequence Type

ISSN: 2047-2994