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Table 2 Pseudomonas aeruginosa (138 strains): results of GDM versus BMD as the reference method

From: Gradient diffusion antibiogram used directly on bronchial aspirates for a rapid diagnosis of ventilator-associated pneumonia

Antibiotic/method

Range

MIC 50

MIC 90

Susceptible (%)

Intermediate (%)

Resistant (%)

Kappa

Minor error (%)

Major and very major error (%)

Ceftazidime GDM

0.064- > 256

2

192

102 (73.9)

13 (9.4)

23 (16.7)

81.7

9 (6.5)

1 (0.7)*

Ceftazidime BMD

< 0.06- > 32

4

> 32

106 (76.8)

6 (4.3)

26 (18.8)

Ceftolozane-tazobactam GDM

0.047- > 256

0.5

1.5

135 (97.8)

3 (2.2)

85.4

1 (0.7)

Ceftolozane-tazobactam BMD

< 0.06- > 64

0.5

4

134 (97.1)

1 (0.7)

3 (2.2)

Meropenem GDM

0.023- > 32

4

> 32

62 (44.9)

20 (14.5)

56 (40.6)

92.9

6 (4.3)

Meropenem BMD

< 0.06- > 32

4

> 32

63 (45.7)

20 (14.5)

55 (39.9)

Doripenem GDM

0.004- > 32

4

> 32

60 (43.5)

25 (18.1)

53 (38.4)

89.6

8 (5.8)

1 (0.7)

Doripenem BMD

< 0.06- > 32

4

32

62 (44.9)

25 (18.1)

51 (37.0)

  1. Range, MIC 50 and MIC 90 are given in mg/mL. GDM = gradient diffusion method, BMD = broth microdilution method. *This was a very major error i.e., susceptible by GDM and resistant by BMD