Risk prediction for 30-day mortality among patients with Clostridium difficile infections: a retrospective cohort study

Table 4 Risk prediction model for prolonged (> 9 days) length of ICU stay following C. difficile infections (CDI) among adult inpatients with CDI who survived the first 30 days following CDI (N = 307)^a

Variables	Crude OR (95% CI)	P-value	Logistic regression model - Original (N = 99)	P-value	Logistic regression model - Imputed (N = 307)	P-value
Variables	Crude OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value
Age > 65 years old	1.51 (0.88, 2.57)	0.133	1.37 (0.56, 3.36)	0.492	1.28 (0.72, 2.30)	0.400
Malignancy	0.57 (0.32, 1.03)	0.061	0.60 (0.23, 1.60)	0.310	0.54 (0.29, 1.03)	0.061
WBC in tertiles, cells/mm³
1st tertile: < 9440	1.00 (Ref)		1.00 (Ref)		1.00 (Ref)
2nd tertile: 9440 to < 14,600	1.33 (0.68, 2.61)	0.412	1.17 (0.37, 3.74)	0.786	1.19 (0.57, 2.52)	0.640
3rd tertile: ≥ 14,600	2.33 (1.21, 4.50)	0.012	1.21 (0.36, 4.01)	0.756	1.76 (0.84, 3.69)	0.132
Rise in SCr ≥ 1.5-fold	1.48 (0.79, 2.76)	0.217	2.40 (0.92, 6.26)	0.073	1.34 (0.69, 2.59)	0.393
Albumin < 2.5 g/dL	2.22 (1.08, 4.54)	0.030	1.89 (0.72, 4.95)	0.195	1.36 (0.66, 2.82)	0.400
BUN-to-SCr ratio > 20	4.74 (2.66, 8.46)	< 0.001	3.81 (1.51, 9.58)	0.005	4.01 (2.19, 7.33)	< 0.001
Glucose tertiles, mg/dL
1st tertile: < 142	1.00 (Ref)		1.00 (Ref)		1.00 (Ref)
2nd tertile: 142 to < 193	1.61 (0.83, 3.12)	0.161	1.41 (0.46, 4.33)	0.545	1.28 (0.72, 2.30)	0.480
3rd tertile: ≥ 193	1.57 (0.79, 3.11)	0.194	0.87 (0.28, 2.72)	0.812	0.54 (0.29, 1.03)	0.618
C statistic (95% CI)			0.741 (0.639, 0.844)		0.737 (0.671, 0.804)

Abbreviations: BUN blood urea nitrogen, CI confidence interval, OR odds ratio, Ref reference, SCr serum creatinine, WBC white blood cell count
^aWe included variables in a logistic regression model and evaluated the discrimination performance using conventional c statistic.

ISSN: 2047-2994