Bombyx mori gloverin A2 alleviates enterotoxigenic Escherichia coli-induced inflammation and intestinal mucosa disruption

Lin, Qian; Su, Guoqi; Wu, Aimin; Chen, Daiwen; Yu, Bing; Huang, Zhiqing; Luo, Yuheng; Mao, Xiangbing; Zheng, Ping; Yu, Jie; Luo, Junqiu; He, Jun

doi:10.1186/s13756-019-0651-y

Antimicrobial Resistance & Infection Control

Table 2 Effect of BMGlvA2 on inflammatory cytokines and metabolic indicators in serum

From: Bombyx mori gloverin A2 alleviates enterotoxigenic Escherichia coli-induced inflammation and intestinal mucosa disruption

Indicators	-K88			+K88			P value
Indicators	0.0 mg/kg	4.0 mg/kg	8.0 mg/kg	0.0 mg/kg	4.0 mg/kg	8.0 mg/kg	Interaction	K88	A
IL-1β ng/mL	219.90 ± 0.01	220.10 ± 0.02	220.10 ± 0.03	220.00 ± 0.04	220.10 ± 0.03	220.00 ± 0.02	0.261	0.847	0.371
IL-6 ng/mL	9.14 ± 0.1027^b	9.47 ± 0.14^b	9.06 ± 0.08^b	79.25 ± 4.88^a	28.52 ± 5.10^b	9.54 ± 0.09^b	< 0.0001	< 0.0001	< 0.0001
TNFα ng/mL	215.60 ± 0.07^b	215.90 ± 0.16^b	215.70 ± 0.08^b	230.50 ± 1.68^a	218.10 ± 0.70^b	215.80 ± 0.10^b	< 0.0001	< 0.001	< 0.001
D-LA μg/L	3.27 ± 0.00	3.28 ± 0.01	3.23 ± 0.03	3.32 ± 0.00	3.29 ± 0.01	3.28 ± 0.01	0.261	0.847	0.371
CRP mg/L	4.32 ± 0.17^ab	3.93 ± 0.23^b	2.67 ± 0.09^b	4.70 ± 0.38^ab	6.06 ± 0.55^a	4.70 ± 0.25^ab	0.373	0.010	0.138
TP g/L	60.50 ± 0.61^a	58.83 ± 0.23^a	55.52 ± 0.24^ab	52.50 ± 0.73^b	55.87 ± 0.62^ab	57.43 ± 0.46^ab	0.003	0.008	0.721
GLO g/L	28.47 ± 0.35^a	27.67 ± 0.17^a	27.10 ± 0.29^ab	24.82 ± 0.45^b	25.88 ± 0.39^b	27.45 ± 0.29^a	0.069	0.018	0.724
ALB g/L	32.03 ± 0.28^a	31.27 ± 0.10^a	29.52 ± 0.25^ab	27.68 ± 0.31^b	29.98 ± 0.27^ab	29.98 ± 0.22^ab	0.001	0.001	0.296
A/G	1.13 ± 0.01^ab	1.13 ± 0.01^ab	1.09 ± 0.01^b	1.12 ± 0.012^ab	1.16 ± 0.01^a	1.09 ± 0.01^b	0.654	0.681	0.076
UREA mmol/L	8.07 ± 0.11^b	7.81 ± 0.12	7.45 ± 0.07^b	26.24 ± 1.66^a	7.10 ± 0.09^b	8.99 ± 0.07^b	< 0.0001	0.0004	< 0.0001
CREA μmol/L	6.00 ± 0.23^b	6.48 ± 0.19^ab	7.09 ± 0.19^ab	26.25 ± 2.76^a	6.65 ± 0.13^ab	7.08 ± 0.21^ab	0.182	0.113	0.519
ALT U/L	39.83 ± 1.63^a	24.40 ± 0.41^c	18.60 ± 1.85^c	36.33 ± 2.91^ab	27.17 ± 0.99^bc	24.60 ± 0.39^c	0.510	0.609	0.001
AST U/L	303.50 ± 25.74^a	147.00 ± 6.33^b	174.30 ± 18.02^b	325.00 ± 26.54^a	131.80 ± 7.45^b	249.70 ± 20.66^ab	0.596	0.466	0.002

The data were expressed as mean ± SEM. Data with different superscript letters in a row indicated that the differences between different treatment groups were statistically significant (p < 0.05). IL-1β interleukin 1 beta, IL-6 interleukin 6, TNFα tumor necrosis factor alpha, D-LA d-lactic acid, CRP c-reactive protein, TP total protein, GLO globulin, ALB albumin, A/G albumin/globulin, CREA creatinine, ALT alanine aminotransferase, AST glutinous straw transaminase

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