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Table 2 Effect of BMGlvA2 on inflammatory cytokines and metabolic indicators in serum

From: Bombyx mori gloverin A2 alleviates enterotoxigenic Escherichia coli-induced inflammation and intestinal mucosa disruption

Indicators-K88+K88P value
0.0 mg/kg4.0 mg/kg8.0 mg/kg0.0 mg/kg4.0 mg/kg8.0 mg/kgInteractionK88A
IL-1β ng/mL219.90 ± 0.01220.10 ± 0.02220.10 ± 0.03220.00 ± 0.04220.10 ± 0.03220.00 ± 0.020.2610.8470.371
IL-6 ng/mL9.14 ± 0.1027b9.47 ± 0.14b9.06 ± 0.08b79.25 ± 4.88a28.52 ± 5.10b9.54 ± 0.09b< 0.0001< 0.0001< 0.0001
TNFα ng/mL215.60 ± 0.07b215.90 ± 0.16b215.70 ± 0.08b230.50 ± 1.68a218.10 ± 0.70b215.80 ± 0.10b< 0.0001< 0.001< 0.001
D-LA μg/L3.27 ± 0.003.28 ± 0.013.23 ± 0.033.32 ± 0.003.29 ± 0.013.28 ± 0.010.2610.8470.371
CRP mg/L4.32 ± 0.17ab3.93 ± 0.23b2.67 ± 0.09b4.70 ± 0.38ab6.06 ± 0.55a4.70 ± 0.25ab0.3730.0100.138
TP g/L60.50 ± 0.61a58.83 ± 0.23a55.52 ± 0.24ab52.50 ± 0.73b55.87 ± 0.62ab57.43 ± 0.46ab0.0030.0080.721
GLO g/L28.47 ± 0.35a27.67 ± 0.17a27.10 ± 0.29ab24.82 ± 0.45b25.88 ± 0.39b27.45 ± 0.29a0.0690.0180.724
ALB g/L32.03 ± 0.28a31.27 ± 0.10a29.52 ± 0.25ab27.68 ± 0.31b29.98 ± 0.27ab29.98 ± 0.22ab0.0010.0010.296
A/G1.13 ± 0.01ab1.13 ± 0.01ab1.09 ± 0.01b1.12 ± 0.012ab1.16 ± 0.01a1.09 ± 0.01b0.6540.6810.076
UREA mmol/L8.07 ± 0.11b7.81 ± 0.127.45 ± 0.07b26.24 ± 1.66a7.10 ± 0.09b8.99 ± 0.07b< 0.00010.0004< 0.0001
CREA μmol/L6.00 ± 0.23b6.48 ± 0.19ab7.09 ± 0.19ab26.25 ± 2.76a6.65 ± 0.13ab7.08 ± 0.21ab0.1820.1130.519
ALT U/L39.83 ± 1.63a24.40 ± 0.41c18.60 ± 1.85c36.33 ± 2.91ab27.17 ± 0.99bc24.60 ± 0.39c0.5100.6090.001
AST U/L303.50 ± 25.74a147.00 ± 6.33b174.30 ± 18.02b325.00 ± 26.54a131.80 ± 7.45b249.70 ± 20.66ab0.5960.4660.002
  1. The data were expressed as mean ± SEM. Data with different superscript letters in a row indicated that the differences between different treatment groups were statistically significant (p < 0.05). IL-1β interleukin 1 beta, IL-6 interleukin 6, TNFα tumor necrosis factor alpha, D-LA d-lactic acid, CRP c-reactive protein, TP total protein, GLO globulin, ALB albumin, A/G albumin/globulin, CREA creatinine, ALT alanine aminotransferase, AST glutinous straw transaminase