Bombyx mori gloverin A2 alleviates enterotoxigenic Escherichia coli-induced inflammation and intestinal mucosa disruption

Table 3 Effect of BMGlvA2 on intestinal morphology

Organization	Indicators	-K88			+K88			P value
Organization	Indicators	0.0 mg/kg	4.0 mg/kg	8.0 mg/kg	0.0 mg/kg	4.0 mg/kg	8.0 mg/kg	Interaction	K88	A
Duodenum	Villus height (μm)	420.14 ± 8.40^a	434.40 ± 14.82^a	417.23 ± 6.45^a	317.27 ± 6.89^c	394.78 ± 8.47^ab	343.29 ± 6.51^b	0.374	< 0.0001	0.117
	Crypt depth (μm)	106.59 ± 2.35^ab	99.25 ± 2.28^ab	93.80 ± 1.89^b	115.07 ± 2.52^a	116.02 ± 4.49^a	81.47 ± 1.21^c	0.086	0.424	0.002
	V/C	3.10 ± 0.12	4.36 ± 0.09	4.50 ± 0.11	2.77 ± 0.04	3.57 ± 0.16	4.22 ± 0.07	0.183	0.001	0.002
Jejunum	Villus height (μm)	211.80 ± 2.34^ab	231.49 ± 11.34^a	195.86 ± 4.34^ab	172.00 ± 5.217^b	179.65 ± 9.01^b	181.40 ± 3.99^b	0.526	0.014	0.565
	Crypt depth (μm)	91.64 ± 3.49	90.52 ± 3.20	75.90 ± 2.14	79.59 ± 2.49	77.33 ± 3.37	74.45 ± 3.78	0.703	0.166	0.356
	V/C	2.39 ± 0.08	2.54 ± 0.08	2.63 ± 0.07	2.17 ± 0.03	2.31 ± 0.05	2.57 ± 0.10	0.850	0.250	0.217
Ileum	Villus height (μm)	331.30 ± 18.31	352.29 ± 14.47	350.19 ± 6.04	319.60 ± 6.21	235.76 ± 13.57	332.22 ± 14.50	0.986	0.671	0.779
	Crypt depth (μm)	91.40 ± 2.84^b	102.19 ± 3.72^ab	92.05 ± 0.99^b	123.23 ± 3.56^a	103.59 ± 5.33^ab	94.09 ± 2.38^b	0.125	0.090	0.241
	V/C	3.66 ± 0.20^a	3.46 ± 0.10^ab	3.81 ± 0.068^a	2.61 ± 0.07^b	3.38 ± 0.05^ab	3.51 ± 0.10^ab	0.245	0.063	0.245

The data were expressed as mean ± SEM. Data with different superscript letters in a row indicated that the differences between different treatment groups were statistically significant (p < 0.05).V/C, the ratio of villus height to crypt depth

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