One-way deterministic sensitivity analysis for CAZ-AVI sequence vs. Ceftolozane/Tazobactam sequence, INB based on a willingness-to-pay threshold. Abbreviations: CAZ-AVI ceftazidime-avibactam, cIAI complicated intra-abdominal infection, EOT end-of-treatment, INB incremental net benefit, Prob probability, TOC test-of-cure, Tx treatment
. CAZ-AVI sequence: CAZ-AVI plus metronidazole, followed by colistin + tigecycline + high-dose meropenem.
Ceftolozane/tazobactam sequence: Ceftolozane/tazobactam plus metronidazole, followed by colistin + tigecycline + high-dose meropenem.
Note: A positive INB indicates the CAZ-AVI sequence is cost effective compared to the ceftolozane/ tazobactam sequence, and vice versa