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Table 2 Antibiotic susceptibility tests by pathogen and continents

From: Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis

 AmpicillinThird generation cephalosporinsGentamicinAmikacinChloramphenicolCotrimoxazoleCiprofloxacinNalidixic acidClindamycin
S. aureusAfrica37/369 (10.0)91/129 a (70.5)372/414 (89.9)0/0 (−)234/373 (62.7)180/351 (51.3)0/0 (−)0/0 (−)16/22 (72.7)
Asia12/77 (15.6)39/43 a (90.7)155/186 (83.3)63/81 (77.8)66/85 (77.6)63/79 (79.7)0/0 (0.0)0/0 (−)55/76 (72.4)
Total49/446 (11.0)130/172 a (75.6)527/600 (87.8)63/81 (77.8)300/458 (65.5)243/430 (56.5)0/0 (−)0/0 (−)71/98 (72.4)
S. pneumoniaeAfrica531/569 b (93.3)132/132 (100.0)2/20 (10.0)0/0 (−)556/605 (91.9)347/596 (58.2)0/0 (−)0/0 (−)20/20 (100.0)
Asia25/32 b (78.1)0/0 (−)0/0 (−)0/0 (−)4/4 (100.0)1/5 (20.0)0/0 (−)0/0 (−)0/0 (−)
Total556/601 b (92.5)132/132 (100.0)2/20 (10.0)0/0 (−)560/609 (92.0)348/601 (57.9)0/0 (−)0/0 (−)20/20 (100.0)
E. coliAfrica13/236 (5.5)52/66 (78.8)183/265 (69.1)8/8 (100.0)79/281 (28.1)37/251 (14.7)9/9 (100.0)0/0 (−)
Asia27/105 (25.7)64/93 (68.8)37/66 (56.1)38/54 (70.4)41/109 (37.6)20/55 (36.4)38/60 (63.3)46/53 (86.8)
Total40/341 (11.7)116/159 (73.0)220/331 (66.5)46/62 (74.2)120/390 (30.8)57/306 (18.6)47/69 (68.1)46/53 (86.8)
Klebsiella sp.Africa0/20 (0.0)0/0 (−)16/19 (84.2)8/8 (100.0)7/19 (36.8)6/18 (33.3)0/0 (−)0/0 (−)
Asia30/489 (6.1)123/477 (25.8)93/480 (19.4)247/471 (52.4)100/489 (20.4)12/18 (66.7)183/471 (38.9)15/18 (83.3)
Total30/509 (5.9)123/477 (25.8)109/499 (21.8)255/479 (53.2)107/508 (21.1)18/36 (50.0)183/471 (38.9)15/18 (83.3)
non-typhoidal SalmonellaAfrica196/654 (30.0)94/94 (100.0)488/564 (86.5)9/10 (90.0)316/656 (48.2)232/646 (35.9)7/7 (100.0)0/0 (−)
Asia36/44 (81.8)39/39 (100.0)0/0 (−)0/0 (−)6/7 (85.7)39/44 (88.6)35/36 (97.2)7/7 (100.0)
Total232/698 (33.2)133/133 (100.0)488/564 (86.5)9/10 (90.0)322/663 (48.6)271/690 (39.3)42/43 (97.7)7/7 (100.0)
S. TyphiAfrica
Asia333/499 (66.7)300/323 (92.9)139/190 (73.2)162/190 (85.3)332/493 (67.3)279/332 (84.0)210/245 (85.7)202/274 (73.7)
Total333/499 (66.73)300/323 (92.9)139/190 (73.2)162/190 (85.3)332/493 (67.3)279/332 (84.0)210/245 (85.7)202/274 (73.7)
H. influenzaeAfrica80/157 (50.95)0/0 (−)22/23 (95.7)0/0 (−)70/147 (47.6)204/388 (52.6)0/0 (−)0/0 (−)
Asia 
Total80/157 (50.95)0/0 (−)22/23 (95.7)0/0 (−)70/147 (47.6)204/388 (52.6)0/0 (−)0/0 (−)
  1. Results are shown as: n susceptible isolates/n isolates tested (%) aIn 2 studies [32, 33], we made the assumption that oxacillin susceptible isolates were susceptible to 3rd geneneration cephalosporins, whereas susceptibility to 3rd geneneration cephalosporins was specifically tested in 2 other studies [21, 28]
  2. b S. pneumoniae isolates have been tested to penicillin