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Table 2 Interrupted time-series regression analysis of antibiotic consumption (carbapenems and all antibiotics) and antibiotic free-days in vascular and general surgery wards (Adjusted for the proportion of men, age distribution, length of stay and seasonality)

From: Persuasive antimicrobial stewardship intervention in the context of a KPC outbreak: a controlled interrupted time series analysis

 Vascular SurgeryGeneral Surgery
Coefficient (95%CI)p-valueCoefficient (95%CI)p-value
Carbapenem consumption (DDD/100 PD)
 Baseline level (β0)*19.38 (16.36; 22.39) 8..60 (7.47; 9.72) 
 Pre-intervention slope (β1)−0.16 (− 0.28; − 0.04)0.008− 0.05 (− 0.11; 0.00)0.059
 Level change (post intervention)  (β2)−11.14 (− 16.18; − 6.10)< 0.001−1.88 (− 4.18; 0 .43)0.109
 Slope post-intervention (β3)0.15 (− 0.01; 0.31)0.0630.06 (− 0.07; 0.19)0.352
Overall antibiotic consumption (DDD/100 PD)
 Baseline level (β0) *56.00 (52.22; 59.78) 48.04 (48.80; 51.26) 
 Pre-intervention slope (β1)0.10 (−0.09; 0.29)0.302−0.04 (− 0.18; 0.09)0.524
 Level change (post intervention)  (β2)2.73 (−7.95; 13.42)0.611−0.30 (−4.30; 3.70)0.880
 Slope post-intervention (β3)−1.07 (−1.54; −0.61)< 0.0010 .45 (0 .21; 0 .68)< 0.001
Days without antibiotic (%)
 Baseline level (β0) *40.87 (38.06; 43.67) 54.38 (52.33; 56.44) 
 Pre-intervention slope (β1)0.12 (−0.01; 0.26)0.0760.12 (0 .03; 0.20)0.010
 Level change (post intervention)  (β2)3.18 (−1.86; 8.22)0.211−1.46 (−3.56; 0 .62)0.165
 Slope post-intervention (β3)0.13 (−0.17; 0.42)0.395−0.16 (− 0.31; − 0.02)0.028
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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