The potential negative impact of antibiotic pack on antibiotic stewardship in primary care in Switzerland: a modelling study

Table 1 Pack-antibiotic regimen matching (optimal and adequate) for adults

Regimen				CAP	Otitis media	Tonsillopharyngitis	Sinusitis	UTI women	UTI men
Substance	Single dose	N doses/day	Duration (in days)	CAP	Otitis media	Tonsillopharyngitis	Sinusitis	UTI women	UTI men
WHO group: ACCESS
Amoxicillin	375 mg	3	5			15 (+ 1)
	500 mg	3	7				21 (−1)
	750 mg	3	7	21 (−1)	21 (− 1)		21 (− 1)
	1000 mg	2	5	10			10^a
	1000 mg	2	7	14			14^a
	1000 mg	3	5	15 (−1)	15 (−1)^a		15 (−1)^a
	1000 mg	3	7	21 (−1)			21 (− 1)
Amoxicillin/clavulanate	625 mg	3	3					9 (+ 1)^a
	625 mg	3	7	21 (−1)	21 (−1)		21 (− 1)
	1000 mg	2	10	20	20		20
	1000 mg	4	5				20^a
Doxycycline	100 mg	2	5	10	10		10^a
Cotrimoxazole	960 mg	2	5		10^a		10		10
Cotrimoxazole	960 mg	2	10		20
WHO group: WATCH
Azithromycin	500 mg	1	3		3	3	3
Azithromycin	500 mg	1	5		5(+ 1)	5(+ 1)
Ciprofloxacin	500 mg	2	5						10
Clarithromycin	250 mg	2	7		14		14
	250 mg	2	10			20
	500 mg	2	7	14	14
	500 mg	2	10	20	20	20
Levofloxacin	500 mg	1	5	5			5
	500 mg	1	7	7			7
	500 mg	1	10				10
	500 mg	2	5	10
	500 mg	2	7	14
Moxifloxacin	400 mg	1	5	5
	400 mg	1	7	7			7
	400 mg	1	10	10			10
Norfloxacin	400 mg	2	3					6^a
WHO group: UNCLASSIFIED
Cefuroxime	250 mg	2	7		14		14
Cefuroxime	500 mg	2	7	14	14		14^a	14^a
Fosfomycin	3000 mg	1	1					1^a

^apart of the SSI-Guidelines (ssi.guidelines.ch)
+1 = optimized by adding a single dose; -1 = optimized by subtracting a single dose
CAP Community-acquired pneumonia, UTI Urinary tract infection
The regimens are shown together with the number of dosing units required for that regimen. Antibiotics are listed alphabetically by WHO Access or Watch groups with unclassified antibiotics listed separately. Bold font indicates availability of an optimal pack for the listed antibiotic and regimen. Normal font indicates availability of an adequate pack for the listed antibiotic and regimen, meaning that matching could be achieved by adding or dropping a single dosing unit. Listed regimens represent 47.1% (33/70 regimens) for adults. All remaining regimens did not have matching optimal or adequate packs

ISSN: 2047-2994