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Table 5 Univariate analysis of risk factors associated with death in KP, CRKP and CSKP BSI

From: Five-year change of prevalence and risk factors for infection and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary hospital in North China

Items

KP BSI

CRKP BSI

CSKP BSI

Death

(n = 121)

Survival

(n = 371)

P

Death

(n = 72)

Survival

(n = 92)

P

Death

(n = 49)

Survival

(n = 279)

P

Male

72(59.5%)

233(62.0%)

0.506

44(61.1%)

66(71.7%)

0.151

28(57.1%)

167(59.9%)

0.721

Age (years)

63(23)

56(24)

<0.001

69(21)

48(29)

<0.001

62(17)

59(20)

0.268

previous hospitalization

98(81.0%)

237(63.9%)

<0.001

60(83.3%)

61(66.3%)

0.014

38(77.6%)

176(63.1%)

0.05

Hospital stay (days)

23(24)

23(23)

0.579

28(27)

36(33)

0.038

16(26)

19(18)

0.072

Hospital stay before bacteremia (days)

bacteremia (days)

13(26)

5(14)

<0.001

14(28)

14(14)

0.041

6(24)

3(12)

0.056

APACHE II SCORE

13(7)

8(5)

<0.001

14(8)

12(5)

<0.001

12(8)

8(4)

<0.001

ICU admission

67(55.4%)

107(28.8%)

<0.001

53(73.6%)

63(68.5%)

0.473

14(28.6%)

44(15.8%)

0.03

Use of systemic steroids

37(30.6%)

77(20.8%)

0.026

23(31.9%)

23(25.0%)

0.326

14(28.6%)

54(19.4%)

0.142

Chemotherapy/Radiotherapy

31(25.6%)

71(20.7%)

0.127

17(23.6%)

13(14.1%)

0.119

14(28.6%)

58(20.8%)

0.225

Use of immunosuppressant

33(27.3%)

80(21.6%)

0.195

17(23.6%)

17(18.5%)

0.421

16(32.7%)

63(22.6%)

0.128

Hypertension

57(47.1%)

127(34.2%)

0.011

37(51.4%)

35(38.0%)

0.087

20(40.8%)

92(33.0%)

0.286

Coronary heart disease

33(27.3%)

71(19.1%)

0.057

25(34.7%)

12(13.0%)

0.001

8(16.3%)

59(21.1%)

0.44

Diabetes mellitus

36(29.8%)

122(32.9%)

0.522

21(29.2%)

13(14.1%)

0.018

15(30.6%)

109(39.1%)

0.26

COPD

11(9.1%)

12(3.2%)

0.008

8(11.1%)

6(6.5%)

0.297

3(6.1%)

6(2.2%)

0.273

Renal diseases

18(14.9%)

24(6.5%)

0.004

12(16.7%)

10(10.9%)

0.280

6(12.2%)

14(5.0%)

0.104

Autoimmune diseases

6(5.0%)

11(3.0%)

0.297

4(5.6%)

3(3.3%)

0.740

2(4.1%)

8(2.9%)

0.996

Solid tumor

27(22.3%)

37(10.0%)

<0.001

10(13.9%)

9(9.8%)

0.415

17(34.7%)

28(10.0%)

<0.001

Hematologic malignancy

21(17.4%)

58(15.6%)

0.654

14(19.4%)

10(10.9%)

0.123

7(14.3%)

48(17.2%)

0.614

Enema

6(5.0%)

17(4.6%)

0.865

6(8.3%)

8(8.7%)

0.934

0

9(3.2%)

0.432

Nasogastric catheter

70(57.9%)

123(33.2%)

<0.001

52(72.2%)

65(70.7%)

0.825

18(36.7%)

58(20.8%)

0.015

Urinary catheter

74(61.2%)

147(39.6%)

<0.001

54(75.0%)

72(78.3%)

0.623

20(40.8%)

75(26.7%)

0.047

CVC

95(78.5%)

173(46.6%)

<0.001

65(90.3%)

77(83.7%)

0.220

30(61.2%)

96(34.4%)

<0.001

Peripheral arterial catheter

16(13.2%)

35(9.4%)

0.235

12(16.7%)

22(23.9%)

0.256

4(8.2%)

13(4.7%)

0.502

Blood purification

19(15.7%)

28(7.5%)

0.008

16(22.2%)

20(21.7%)

0.941

3(6.1%)

8(2.9%)

0.461

Tracheal cannula

51(42.1%)

82(22.1%)

<0.001

42(58.3%)

52(56.5%)

0.816

9(18.4%)

30(10.8%)

0.129

Tracheostomy

21(17.4%)

35(9.4%)

0.017

16(22.2%)

19(20.7%)

0.808

5(10.2%)

16(5.7%)

0.239

Non-invasive ventilation

23(19.0%)

14(3.8%)

<0.001

14(19.4%)

8(8.7%)

0.045

9(18.4%)

6(2.2%)

<0.001

Gastroscopy

3(2.5%)

9(2.4%)

1.000

2(2.8%)

4(4.3%)

0.910

1(2.0%)

5(1.8%)

1.000

Colonoscopy

1(0.8%)

2(0.5%)

1.000

1(1.4%)

1(1.1%)

1.000

0

1(0.4%)

1.000

Bronchoscopy

20(16.5%)

19(5.1%)

<0.001

20(27.8%)

15(16.3%)

0.075

0

4(1.4%)

0.890

Sputum suction

58(47.9%)

92(24.8%)

<0.001

46(63.9%)

56(60.9%)

0.692

12(24.5%)

36(12.9%)

0.034

Thoracentesis

19(15.7%)

27(7.3%)

0.006

17(23.6%)

20(21.7%)

0.776

2(4.1%))

7(2.5%)

0.883

Abdominocentesis

11(9.1%)

13(3.5%)

0.013

10(13.9%)

9(9.8%)

0.415

1 (2.0%)

4(1.4%)

1.000

Bone marrow puncture

28(23.1%)

54(14.6%)

0.028

17(23.6%)

9(9.8%)

0.016

11(22.4%)

45(16.1%)

0.278

Lumbar puncture

11(9.1%)

37(10.0%)

0.776

9(12.5%)

15(16.3%)

0.494

2(4.1%)

22(7.9%)

0.519

Previous surgery

45(37.2%)

124(33.4%)

0.449

33(45.8%)

54(58.7%)

0.101

12(24.5%)

70(25.1%)

0.929

Abdominal surgery

36(29.8%)

102(27.5%)

0.631

19(26.4%)

31(33.7%)

0.313

17(34.7%)

71(25.4%)

0.178

Enteral nutrition

47(38.8%)

77(20.8%)

<0.001

38(52.8%)

42(45.7%)

0.365

9(18.4%)

35(12.5%)

0.270

Parenteral nutrition

Previous use of antibiotics

61(50.4%)

107(28.8%)

<0.001

39(54.2%)

56(60.9%)

0.388

22(44.9%)

51(18.3%)

<0.001

Any antibiotics

106(87.6%)

281(75.7%)

0.006

71(98.6%)

87(94.6%)

0.171

35(71.4%)

194(69.5%)

0.790

Carbapenems

65(53.7%)

75(20.2%)

<0.001

51(70.8%)

45(48.9%)

0.005

14(28.6%)

30(10.8%)

0.001

Glycopeptides

38(31.4%)

47(12.7%)

<0.001

30(41.7%)

31(33.7%)

0.295

8(16.3%)

16(5.7%)

0.02

Quinolones

52(43.0%)

113(30.5%)

0.011

41(56.9%)

39(42.4%)

0.064

11(22.4%)

74(26.5%)

0.548

3rd/4th generation cephalosporins

22(18.2%)

55(14.8%)

0.377

17(23.6%)

13(14.1%)

0.119

5(10.2%)

42(15.1%)

0.372

1st/2nd generation cephalosporins

14(11.6%)

51(13.7%)

0.539

8(11.1%)

15(16.3%)

0.342

6(12.2%)

36(12.9%)

0.899

Penicillins

5(4.1%)

22(5.9%)

0.451

2(2.8%)

4(4.3%)

0.910

3(6.1%)

18(6.5%)

1.000

β-lactamase inhibitor

71(58.7%)

136(36.7%)

<0.001

54(75.0%)

49(53.3%)

0.004

17(34.7%)

87(31.2%)

0.626

Aminoglycosides

8(6.6%)

3(0.8%)

0.001

6(8.3%)

1(1.1%)

0.059

2(4.1%)

1(0.7%)

0.108

Linezolid

14(11.6%)

10(2.7%)

<0.001

13(18.1%)

6(6.6%)

0.024

1(2.0%)

4(1.4%)

0.557

Tigecycline

26(21.5%)

22(5.9%)

<0.001

20(27.8%)

18(19.6%)

0.216

6(12.2%)

4(1.4%)

<0.001

Daptomycin

2(1.7%)

1(0.3%)

0.305

2(2.8%)

1(1.1%)

0.830

0

0

–

Nitroimidazoles

7(5.8%)

14(3.8%)

0.342

6(8.3%)

2(2.2%)

0.146

1(2.0%)

12(4.3%)

0.726

KP detection in other sites

68(56.2%)

118(31.8%)

<0.001

52(72.2%)

56(60.9%)

0.128

16(32.7%)

62(22.2%)

0.114

CRKP

72(59.5%)

92(24.8%)

<0.001

      
  1. KP Klebsiella pneumoniae, CRKP Carbapenem-resistant KP, CSKP Carbapenem-susceptible KP, BSI bloodstream infections, APACHE Acute Physiology and Chronic Health Evaluation, ICU Intensive Care Unit, COPD chronic obstructive pulmonary disease, CVC central venous catheter